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Literature summary extracted from

  • Yamasaki, C.; Nishikawa, K.; Zeng, X.T.; Katayama, Y.; Natori, Y.; Komatsu, N.; Oda, T.
    Induction of cytokines by toxins that have an identical RNA N-glycosidase activity: Shiga toxin, ricin, and modeccin (2004), Biochim. Biophys. Acta, 1671, 44-50.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.2.2.22 additional information a GST-tagged chimeric pentameric mutant enzyme comprising parts of ricin and of Shiga toxin shows no RNA N-glycosidase activity Ricinus communis
3.2.2.22 additional information a GST-tagged chimeric pentameric mutant enzyme comprising parts of ricin and of Shiga toxin shows no RNA N-glycosidase activity Shigella dysenteriae

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.2.22 brefeldin A inhibits interleukin-8 induction by the enzymethrough inhibition of the toxin transport from Golgi to the cytosol, overview Ricinus communis
3.2.2.22 brefeldin A inhibits interleukin-8 induction by the enzyme through inhibition of the toxin transport from Golgi to the cytosol, overview Shigella dysenteriae
3.2.2.22 Gb3-liposomes inhibition of cell toxicity Shigella dysenteriae
3.2.2.22 lactose inhibition of cell toxicity Ricinus communis
3.2.2.22 additional information no inhibition of cell toxicity by Gb4- and Gb3-liposomes, and sucrose Ricinus communis
3.2.2.22 additional information no inhibition of cell toxicity by Gb4-liposomes, lactose, and sucrose Shigella dysenteriae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.2.22 extracellular the enzyme enters target cells via its cell surface receptor Ricinus communis
-
-
3.2.2.22 extracellular the enzyme enters target cells via its cell surface receptor Corynebacterium diphtheriae
-
-
3.2.2.22 extracellular the enzyme enters target cells via its cell surface receptor Shigella dysenteriae
-
-
3.2.2.22 extracellular the enzyme enters target cells via its cell surface receptor Adenia digitata
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.2.22 additional information Corynebacterium diphtheriae the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells ?
-
 ?
3.2.2.22 additional information Adenia digitata the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells ?
-
 ?
3.2.2.22 additional information Ricinus communis the enzyme induces cytokinins, e.g. interleukin-8, the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells, the enzyme targets the cell surface of the target cell followed by endocytosis and transport to the endoplasmic reticulum where the active part is set free and translocated to the cytosol dependent on several factors, in the cytosol the toxin attacks its target ?
-
 ?
3.2.2.22 additional information Shigella dysenteriae the enzyme induces cytokinins, e.g. interleukin-8, the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells, the enzyme targets the cell surface of the target cell followed by endocytosis and transport to the endoplasmic reticulum where the active part is set free and translocated to the cytosol dependent on several factors, in the cytosol the toxin attacks its target ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.22 Adenia digitata
-
-
-
3.2.2.22 Corynebacterium diphtheriae
-
-
-
3.2.2.22 Ricinus communis
-
-
-
3.2.2.22 Shigella dysenteriae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.2.22 commercial preparation
-
 Corynebacterium diphtheriae
-
3.2.2.22 commercial preparation
-
 Adenia digitata
-
3.2.2.22 seed
-
 Ricinus communis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.22 additional information the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells Corynebacterium diphtheriae ?
-
 ?
3.2.2.22 additional information the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells Adenia digitata ?
-
 ?
3.2.2.22 additional information the enzyme induces cytokinins, e.g. interleukin-8, the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells, the enzyme targets the cell surface of the target cell followed by endocytosis and transport to the endoplasmic reticulum where the active part is set free and translocated to the cytosol dependent on several factors, in the cytosol the toxin attacks its target Ricinus communis ?
-
 ?
3.2.2.22 additional information the enzyme induces cytokinins, e.g. interleukin-8, the cytotoxic enzyme inhibits protein synthesis by inactivation of ribosomes in target cells, e.g. Caco-2 and Vero cells, the enzyme targets the cell surface of the target cell followed by endocytosis and transport to the endoplasmic reticulum where the active part is set free and translocated to the cytosol dependent on several factors, in the cytosol the toxin attacks its target Shigella dysenteriae ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.2.2.22 dimer (alphabeta) structure Ricinus communis
3.2.2.22 dimer (alphabeta) structure Adenia digitata
3.2.2.22 pentamer StxB Shigella dysenteriae

Synonyms

EC Number Synonyms Comment Organism
3.2.2.22 diphtheria toxin
-
 Corynebacterium diphtheriae
3.2.2.22 modeccin
-
 Adenia digitata
3.2.2.22 ricin
-
 Ricinus communis
3.2.2.22 RNA N-glycosidase
-
 Ricinus communis
3.2.2.22 RNA N-glycosidase
-
 Corynebacterium diphtheriae
3.2.2.22 RNA N-glycosidase
-
 Shigella dysenteriae
3.2.2.22 RNA N-glycosidase
-
 Adenia digitata
3.2.2.22 Shiga toxin
-
 Shigella dysenteriae
3.2.2.22 Stx
-
 Shigella dysenteriae
3.2.2.22 StxB
-
 Shigella dysenteriae
3.2.2.22 type II ribosome-inactivating protein
-
 Ricinus communis
3.2.2.22 type II ribosome-inactivating protein
-
 Corynebacterium diphtheriae
3.2.2.22 type II ribosome-inactivating protein
-
 Shigella dysenteriae
3.2.2.22 type II ribosome-inactivating protein
-
 Adenia digitata

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.2.22 37
-
 assay at Shigella dysenteriae