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Literature summary extracted from

  • Strauss, E.; Zhai, H.; Brand, L.A.; McLafferty, F.W.; Begley, T.P.
    Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent (2004), Biochemistry, 43, 15520-15533.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.36 4'-phospho-N-(1-mercaptomethyl-cyclopropyl)-pantothenamide i.e. PPanDELTASH, mechanism-based inhibitor, alkylating C173 residue of enzyme Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.36 0.118
-
 (R)-4'-phospho-N-pantothenoylcysteine pH 7.6, 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.36 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.1.36 N-[(R)-4'-phosphopantothenoyl]-L-cysteine = pantotheine 4'-phosphate + CO2 C173 serves as an active site acid in the protonation of the enethiolate intermediate Homo sapiens
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.36 (R)-4'-phospho-N-pantothenoylcysteine
-
 Homo sapiens pantotheine 4'-phosphate + CO2
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.1.1.36 2.9
-
 (R)-4'-phospho-N-pantothenoylcysteine pH 7.6, 37°C Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.1.36 2.58
-
 4'-phospho-N-(1-mercaptomethyl-cyclopropyl)-pantothenamide pH 7.6, 37°C Homo sapiens