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Literature summary extracted from

  • Sono, M.; Cady, S.G.
    Enzyme kinetic and spectroscopic studies of inhibitor and effector interactions with indoleamine 2,3-dioxygenase. 1. Norharman and 4-phenylimidazole binding to the enzyme as inhibitors and heme ligands (1989), Biochemistry, 28, 5392-5399.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.52 4-phenylimidazole heme ligand, non competitive, 0.1 M potassium phosphate buffer (pH 5.5-8), 0.1 M Tris-HCl buffer (pH 7.5-8), 25°C Oryctolagus cuniculus
1.13.11.52 cyanide heme ligand, competitive for the ferric enzyme Oryctolagus cuniculus
1.13.11.52 D-tryptophan
-
 Oryctolagus cuniculus
1.13.11.52 norharman non competitive, competitive for the ferric enzyme, 0.1 M potassium phosphate buffer (pH 5.5-8), 0.1 M Tris-HCl buffer (pH 7.5-8), 25°C Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.52 0.83
-
 D-tryptophan 0.1 M potassium phosphate buffer (pH 6-8), 0.025 mM methylene blue, 0.2 mg catalase, 10 mM ascorbic acid, 50 nM dioxygenase, 25°C Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 D-tryptophan + O2 Oryctolagus cuniculus
-
 N-formyl-D-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2 Oryctolagus cuniculus
-
 N-formyl-L-kynurenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.52
-
 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.52 small intestine
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 D-tryptophan + O2
-
 Oryctolagus cuniculus N-formyl-D-kynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Oryctolagus cuniculus N-formyl-L-kynurenine
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.52 7
-
-
 Oryctolagus cuniculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.13.11.52 5.5 8
-
 Oryctolagus cuniculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.52 0.05
-
 D-tryptophan 0.1 M potassium phosphate buffer (pH 6-8), 0.025 mM methylene blue, 0.2 mg catalase, 10 mM ascorbic acid, 50 nM dioxygenase, 25°C Oryctolagus cuniculus