EC Number | Cloned (Comment) | Organism |
---|---|---|
3.1.3.4 | overexpression of isozyme LPP1 in Rat2 fibroblasts | Rattus norvegicus |
3.1.3.4 | separate overexpression of isozymes LPP1, LPP2, or LPP3 in HEK-293 cells reducing lysophosphatidic acid-stimulated p42/p44 MAPK activation | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.3.4 | additional information | construction of LPP3 or LPP1 knockout mice, the embryonic fibroblasts of these transgenic mice show diacylglycerol levels and reduced phosphatidic acid levels | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.3.4 | caveola | - |
Mus musculus | 5901 | - |
3.1.3.4 | caveola | - |
Homo sapiens | 5901 | - |
3.1.3.4 | caveola | - |
Rattus norvegicus | 5901 | - |
3.1.3.4 | caveola | - |
Canis lupus familiaris | 5901 | - |
3.1.3.4 | membrane | integral | Mus musculus | 16020 | - |
3.1.3.4 | membrane | integral | Homo sapiens | 16020 | - |
3.1.3.4 | membrane | integral | Rattus norvegicus | 16020 | - |
3.1.3.4 | membrane | integral | Canis lupus familiaris | 16020 | - |
3.1.3.4 | additional information | the enzymes act intra- and extracellularly | Mus musculus | - |
- |
3.1.3.4 | additional information | the enzymes act intra- and extracellularly | Homo sapiens | - |
- |
3.1.3.4 | additional information | the enzymes act intra- and extracellularly | Rattus norvegicus | - |
- |
3.1.3.4 | additional information | the enzymes act intra- and extracellularly, the subcellular localization influences the physiological role of the isozymes | Canis lupus familiaris | - |
- |
3.1.3.4 | plasma membrane | the enzymes act on the cytoplasmic and the cell surface side of the membrane | Mus musculus | 5886 | - |
3.1.3.4 | plasma membrane | the enzymes act on the cytoplasmic and the cell surface side of the membrane | Homo sapiens | 5886 | - |
3.1.3.4 | plasma membrane | the enzymes act on the cytoplasmic and the cell surface side of the membrane | Rattus norvegicus | 5886 | - |
3.1.3.4 | plasma membrane | the enzymes act on the cytoplasmic and the cell surface side of the membrane, isozyme LPP1 is located at the apical membrane, isozyme LPP3 is located at the basolateral membrane | Canis lupus familiaris | 5886 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.3.4 | lysophosphatidic acid + H2O | Mus musculus | - |
monoacylglycerol + phosphate | - |
? | |
3.1.3.4 | lysophosphatidic acid + H2O | Homo sapiens | - |
monoacylglycerol + phosphate | - |
? | |
3.1.3.4 | lysophosphatidic acid + H2O | Rattus norvegicus | - |
monoacylglycerol + phosphate | - |
? | |
3.1.3.4 | lysophosphatidic acid + H2O | Canis lupus familiaris | - |
monoacylglycerol + phosphate | - |
? | |
3.1.3.4 | additional information | Mus musculus | LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview | ? | - |
? | |
3.1.3.4 | additional information | Homo sapiens | LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview | ? | - |
? | |
3.1.3.4 | additional information | Rattus norvegicus | LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview | ? | - |
? | |
3.1.3.4 | additional information | Canis lupus familiaris | LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.3.4 | Canis lupus familiaris | - |
isozymes LPP1, LPP-2, and LPP-3 | - |
3.1.3.4 | Homo sapiens | - |
isozymes LPP1, LPP-2, and LPP-3 | - |
3.1.3.4 | Mus musculus | - |
isozymes LPP1, LPP-2, and LPP-3 | - |
3.1.3.4 | Rattus norvegicus | - |
isozymes LPP1, LPP-2, and LPP-3 | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.3.4 | blood platelet | - |
Mus musculus | - |
3.1.3.4 | blood platelet | - |
Homo sapiens | - |
3.1.3.4 | blood platelet | - |
Rattus norvegicus | - |
3.1.3.4 | blood platelet | - |
Canis lupus familiaris | - |
3.1.3.4 | HEK-293 cell | - |
Homo sapiens | - |
3.1.3.4 | kidney | - |
Canis lupus familiaris | - |
3.1.3.4 | MDCK cell | Madine-Darby kidney cell line | Canis lupus familiaris | - |
3.1.3.4 | ovary | - |
Homo sapiens | - |
3.1.3.4 | ovary cancer cell | shows reduced LPP1 activity | Homo sapiens | - |
3.1.3.4 | preadipocyte | - |
Mus musculus | - |
3.1.3.4 | preadipocyte | - |
Homo sapiens | - |
3.1.3.4 | preadipocyte | - |
Rattus norvegicus | - |
3.1.3.4 | preadipocyte | - |
Canis lupus familiaris | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.3.4 | ceramide 1-phosphate + H2O | - |
Mus musculus | ceramide + phosphate | - |
? | |
3.1.3.4 | ceramide 1-phosphate + H2O | - |
Homo sapiens | ceramide + phosphate | - |
? | |
3.1.3.4 | ceramide 1-phosphate + H2O | - |
Rattus norvegicus | ceramide + phosphate | - |
? | |
3.1.3.4 | ceramide 1-phosphate + H2O | - |
Canis lupus familiaris | ceramide + phosphate | - |
? | |
3.1.3.4 | lysophosphatidic acid + H2O | - |
Mus musculus | monoacylglycerol + phosphate | - |
? | |
3.1.3.4 | lysophosphatidic acid + H2O | - |
Homo sapiens | monoacylglycerol + phosphate | - |
? | |
3.1.3.4 | lysophosphatidic acid + H2O | - |
Rattus norvegicus | monoacylglycerol + phosphate | - |
? | |
3.1.3.4 | lysophosphatidic acid + H2O | - |
Canis lupus familiaris | monoacylglycerol + phosphate | - |
? | |
3.1.3.4 | additional information | LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview | Mus musculus | ? | - |
? | |
3.1.3.4 | additional information | LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview | Homo sapiens | ? | - |
? | |
3.1.3.4 | additional information | LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview | Rattus norvegicus | ? | - |
? | |
3.1.3.4 | additional information | LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview | Canis lupus familiaris | ? | - |
? | |
3.1.3.4 | phosphatidic acid + H2O | - |
Mus musculus | diacylglycerol + phosphate | - |
? | |
3.1.3.4 | phosphatidic acid + H2O | - |
Homo sapiens | diacylglycerol + phosphate | - |
? | |
3.1.3.4 | phosphatidic acid + H2O | - |
Rattus norvegicus | diacylglycerol + phosphate | - |
? | |
3.1.3.4 | phosphatidic acid + H2O | - |
Canis lupus familiaris | diacylglycerol + phosphate | - |
? | |
3.1.3.4 | sphingosine 1-phosphate + H2O | - |
Mus musculus | sphingosine + phosphate | - |
? | |
3.1.3.4 | sphingosine 1-phosphate + H2O | - |
Homo sapiens | sphingosine + phosphate | - |
? | |
3.1.3.4 | sphingosine 1-phosphate + H2O | - |
Rattus norvegicus | sphingosine + phosphate | - |
? | |
3.1.3.4 | sphingosine 1-phosphate + H2O | - |
Canis lupus familiaris | sphingosine + phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.3.4 | lipid phosphate phosphatase | - |
Mus musculus |
3.1.3.4 | lipid phosphate phosphatase | - |
Homo sapiens |
3.1.3.4 | lipid phosphate phosphatase | - |
Rattus norvegicus |
3.1.3.4 | lipid phosphate phosphatase | - |
Canis lupus familiaris |
3.1.3.4 | LPP | - |
Mus musculus |
3.1.3.4 | LPP | - |
Homo sapiens |
3.1.3.4 | LPP | - |
Rattus norvegicus |
3.1.3.4 | LPP | - |
Canis lupus familiaris |