BRENDA - Enzyme Database

Lipid phosphate phosphatases and lipid phosphate signalling

Pyne, S.; Long, J.S.; Ktistakis, N.T.; Pyne, N.J.; Biochem. Soc. Trans. 33, 1370-1374 (2005)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
3.1.3.4
overexpression of isozyme LPP1 in Rat2 fibroblasts
Rattus norvegicus
3.1.3.4
separate overexpression of isozymes LPP1, LPP2, or LPP3 in HEK-293 cells reducing lysophosphatidic acid-stimulated p42/p44 MAPK activation
Homo sapiens
Engineering
EC Number
Amino acid exchange
Commentary
Organism
3.1.3.4
additional information
construction of LPP3 or LPP1 knockout mice, the embryonic fibroblasts of these transgenic mice show diacylglycerol levels and reduced phosphatidic acid levels
Mus musculus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
caveola
-
Canis lupus familiaris
5901
-
3.1.3.4
caveola
-
Homo sapiens
5901
-
3.1.3.4
caveola
-
Mus musculus
5901
-
3.1.3.4
caveola
-
Rattus norvegicus
5901
-
3.1.3.4
membrane
integral
Canis lupus familiaris
16020
-
3.1.3.4
membrane
integral
Homo sapiens
16020
-
3.1.3.4
membrane
integral
Mus musculus
16020
-
3.1.3.4
membrane
integral
Rattus norvegicus
16020
-
3.1.3.4
additional information
the enzymes act intra- and extracellularly, the subcellular localization influences the physiological role of the isozymes
Canis lupus familiaris
-
-
3.1.3.4
additional information
the enzymes act intra- and extracellularly
Homo sapiens
-
-
3.1.3.4
additional information
the enzymes act intra- and extracellularly
Mus musculus
-
-
3.1.3.4
additional information
the enzymes act intra- and extracellularly
Rattus norvegicus
-
-
3.1.3.4
plasma membrane
the enzymes act on the cytoplasmic and the cell surface side of the membrane, isozyme LPP1 is located at the apical membrane, isozyme LPP3 is located at the basolateral membrane
Canis lupus familiaris
5886
-
3.1.3.4
plasma membrane
the enzymes act on the cytoplasmic and the cell surface side of the membrane
Homo sapiens
5886
-
3.1.3.4
plasma membrane
the enzymes act on the cytoplasmic and the cell surface side of the membrane
Mus musculus
5886
-
3.1.3.4
plasma membrane
the enzymes act on the cytoplasmic and the cell surface side of the membrane
Rattus norvegicus
5886
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
lysophosphatidic acid + H2O
Mus musculus
-
monoacylglycerol + phosphate
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
Homo sapiens
-
monoacylglycerol + phosphate
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
Rattus norvegicus
-
monoacylglycerol + phosphate
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
Canis lupus familiaris
-
monoacylglycerol + phosphate
-
-
?
3.1.3.4
additional information
Mus musculus
LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview
?
-
-
-
3.1.3.4
additional information
Homo sapiens
LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview
?
-
-
-
3.1.3.4
additional information
Rattus norvegicus
LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview
?
-
-
-
3.1.3.4
additional information
Canis lupus familiaris
LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.3.4
Canis lupus familiaris
-
isozymes LPP1, LPP-2, and LPP-3
-
3.1.3.4
Homo sapiens
-
isozymes LPP1, LPP-2, and LPP-3
-
3.1.3.4
Mus musculus
-
isozymes LPP1, LPP-2, and LPP-3
-
3.1.3.4
Rattus norvegicus
-
isozymes LPP1, LPP-2, and LPP-3
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
blood platelet
-
Canis lupus familiaris
-
3.1.3.4
blood platelet
-
Homo sapiens
-
3.1.3.4
blood platelet
-
Mus musculus
-
3.1.3.4
blood platelet
-
Rattus norvegicus
-
3.1.3.4
HEK-293 cell
-
Homo sapiens
-
3.1.3.4
kidney
-
Canis lupus familiaris
-
3.1.3.4
MDCK cell
Madine-Darby kidney cell line
Canis lupus familiaris
-
3.1.3.4
ovary
-
Homo sapiens
-
3.1.3.4
ovary cancer cell
shows reduced LPP1 activity
Homo sapiens
-
3.1.3.4
preadipocyte
-
Canis lupus familiaris
-
3.1.3.4
preadipocyte
-
Rattus norvegicus
-
3.1.3.4
preadipocyte
-
Homo sapiens
-
3.1.3.4
preadipocyte
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
ceramide 1-phosphate + H2O
-
663994
Mus musculus
ceramide + phosphate
-
-
-
?
3.1.3.4
ceramide 1-phosphate + H2O
-
663994
Homo sapiens
ceramide + phosphate
-
-
-
?
3.1.3.4
ceramide 1-phosphate + H2O
-
663994
Rattus norvegicus
ceramide + phosphate
-
-
-
?
3.1.3.4
ceramide 1-phosphate + H2O
-
663994
Canis lupus familiaris
ceramide + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
663994
Mus musculus
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
663994
Homo sapiens
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
663994
Rattus norvegicus
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
663994
Canis lupus familiaris
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview
663994
Mus musculus
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview
663994
Homo sapiens
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview
663994
Rattus norvegicus
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview
663994
Canis lupus familiaris
?
-
-
-
-
3.1.3.4
phosphatidic acid + H2O
-
663994
Mus musculus
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
phosphatidic acid + H2O
-
663994
Homo sapiens
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
phosphatidic acid + H2O
-
663994
Rattus norvegicus
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
phosphatidic acid + H2O
-
663994
Canis lupus familiaris
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
663994
Mus musculus
sphingosine + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
663994
Homo sapiens
sphingosine + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
663994
Rattus norvegicus
sphingosine + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
663994
Canis lupus familiaris
sphingosine + phosphate
-
-
-
?
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.3.4
overexpression of isozyme LPP1 in Rat2 fibroblasts
Rattus norvegicus
3.1.3.4
separate overexpression of isozymes LPP1, LPP2, or LPP3 in HEK-293 cells reducing lysophosphatidic acid-stimulated p42/p44 MAPK activation
Homo sapiens
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
3.1.3.4
additional information
construction of LPP3 or LPP1 knockout mice, the embryonic fibroblasts of these transgenic mice show diacylglycerol levels and reduced phosphatidic acid levels
Mus musculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.3.4
caveola
-
Canis lupus familiaris
5901
-
3.1.3.4
caveola
-
Homo sapiens
5901
-
3.1.3.4
caveola
-
Mus musculus
5901
-
3.1.3.4
caveola
-
Rattus norvegicus
5901
-
3.1.3.4
membrane
integral
Canis lupus familiaris
16020
-
3.1.3.4
membrane
integral
Homo sapiens
16020
-
3.1.3.4
membrane
integral
Mus musculus
16020
-
3.1.3.4
membrane
integral
Rattus norvegicus
16020
-
3.1.3.4
additional information
the enzymes act intra- and extracellularly, the subcellular localization influences the physiological role of the isozymes
Canis lupus familiaris
-
-
3.1.3.4
additional information
the enzymes act intra- and extracellularly
Homo sapiens
-
-
3.1.3.4
additional information
the enzymes act intra- and extracellularly
Mus musculus
-
-
3.1.3.4
additional information
the enzymes act intra- and extracellularly
Rattus norvegicus
-
-
3.1.3.4
plasma membrane
the enzymes act on the cytoplasmic and the cell surface side of the membrane, isozyme LPP1 is located at the apical membrane, isozyme LPP3 is located at the basolateral membrane
Canis lupus familiaris
5886
-
3.1.3.4
plasma membrane
the enzymes act on the cytoplasmic and the cell surface side of the membrane
Homo sapiens
5886
-
3.1.3.4
plasma membrane
the enzymes act on the cytoplasmic and the cell surface side of the membrane
Mus musculus
5886
-
3.1.3.4
plasma membrane
the enzymes act on the cytoplasmic and the cell surface side of the membrane
Rattus norvegicus
5886
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.3.4
lysophosphatidic acid + H2O
Mus musculus
-
monoacylglycerol + phosphate
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
Homo sapiens
-
monoacylglycerol + phosphate
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
Rattus norvegicus
-
monoacylglycerol + phosphate
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
Canis lupus familiaris
-
monoacylglycerol + phosphate
-
-
?
3.1.3.4
additional information
Mus musculus
LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview
?
-
-
-
3.1.3.4
additional information
Homo sapiens
LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview
?
-
-
-
3.1.3.4
additional information
Rattus norvegicus
LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview
?
-
-
-
3.1.3.4
additional information
Canis lupus familiaris
LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview
?
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.3.4
blood platelet
-
Canis lupus familiaris
-
3.1.3.4
blood platelet
-
Homo sapiens
-
3.1.3.4
blood platelet
-
Mus musculus
-
3.1.3.4
blood platelet
-
Rattus norvegicus
-
3.1.3.4
HEK-293 cell
-
Homo sapiens
-
3.1.3.4
kidney
-
Canis lupus familiaris
-
3.1.3.4
MDCK cell
Madine-Darby kidney cell line
Canis lupus familiaris
-
3.1.3.4
ovary
-
Homo sapiens
-
3.1.3.4
ovary cancer cell
shows reduced LPP1 activity
Homo sapiens
-
3.1.3.4
preadipocyte
-
Canis lupus familiaris
-
3.1.3.4
preadipocyte
-
Rattus norvegicus
-
3.1.3.4
preadipocyte
-
Homo sapiens
-
3.1.3.4
preadipocyte
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.3.4
ceramide 1-phosphate + H2O
-
663994
Mus musculus
ceramide + phosphate
-
-
-
?
3.1.3.4
ceramide 1-phosphate + H2O
-
663994
Homo sapiens
ceramide + phosphate
-
-
-
?
3.1.3.4
ceramide 1-phosphate + H2O
-
663994
Rattus norvegicus
ceramide + phosphate
-
-
-
?
3.1.3.4
ceramide 1-phosphate + H2O
-
663994
Canis lupus familiaris
ceramide + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
663994
Mus musculus
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
663994
Homo sapiens
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
663994
Rattus norvegicus
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
lysophosphatidic acid + H2O
-
663994
Canis lupus familiaris
monoacylglycerol + phosphate
-
-
-
?
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview
663994
Mus musculus
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview
663994
Homo sapiens
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview
663994
Rattus norvegicus
?
-
-
-
-
3.1.3.4
additional information
LPP is involved in regulation of bioactive lipids acting in signalling pathways, physiological roles of enzyme activity at the cell surface and intracellularly, overview
663994
Canis lupus familiaris
?
-
-
-
-
3.1.3.4
phosphatidic acid + H2O
-
663994
Mus musculus
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
phosphatidic acid + H2O
-
663994
Homo sapiens
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
phosphatidic acid + H2O
-
663994
Rattus norvegicus
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
phosphatidic acid + H2O
-
663994
Canis lupus familiaris
diacylglycerol + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
663994
Mus musculus
sphingosine + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
663994
Homo sapiens
sphingosine + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
663994
Rattus norvegicus
sphingosine + phosphate
-
-
-
?
3.1.3.4
sphingosine 1-phosphate + H2O
-
663994
Canis lupus familiaris
sphingosine + phosphate
-
-
-
?