Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lu, H.; Zhu, J.; Zang, Y.; Ze, Y.; Qin, J.
    Cloning, high level expression of human paraoxonase-3 in Sf9 cells and pharmacological characterization of its product (2005), Biochem. Pharmacol., 70, 1019-1025.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.2 expression of PON3 in Spodoptera frugiperda Sf9 cells using the baculovirus expression system Homo sapiens
3.1.1.25 expression of PON3 in Spodoptera frugiperda Sf9 cells using the baculovirus expression system Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.2 EDTA 0.005-0.01 mM Homo sapiens
3.1.1.2 PMSF 1 mM Homo sapiens
3.1.1.25 EDTA 0.005-0.01 mM Homo sapiens
3.1.1.25 PMSF 1 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.2 7.46
-
 phenyl acetate pH 8.0, 37°C Homo sapiens
3.1.1.25 0.84
-
 dihydrocoumarin pH 8.0, 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.2 Homo sapiens Q15166
-
-
3.1.1.25 Homo sapiens Q15166
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.2 additional information the enzyme can delay and inhibit low-density lipoprotein oxidation in a dose-dependent manner Homo sapiens ?
-
 ?
3.1.1.2 phenyl acetate + H2O
-
 Homo sapiens phenol + acetate
-
 ?
3.1.1.25 dihydrocoumarin + H2O
-
 Homo sapiens 3-(2-hydroxyphenyl)propanoic acid
-
 ?
3.1.1.25 additional information the enzyme can delay and inhibit low-density lipoprotein oxidation in a dose-dependent manner Homo sapiens ?
-
 ?
3.1.8.1 phenyl acetate + H2O
-
 Homo sapiens phenol + acetate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.2 37
-
 assay at Homo sapiens
3.1.1.25 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.2 8
-
 assay at Homo sapiens
3.1.1.25 8.5
-
-
 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.1.25 5 10 pH 5.0: about 55% of maximal activity, pH 10.0: about 35% of maximal activity Homo sapiens

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
3.1.1.25 4.5 9 lactonase activity is quite stable Homo sapiens