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Literature summary extracted from

  • Long, J.S.; Yokoyama, K.; Tigyi, G.; Pyne, N.J.; Pyne, S.
    Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration (2006), Biochem. J., 394, 495-500.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.3.4 additional information LPP1 overexpression markedly reduces platelet-derived growth factor-induced activation of p42/p44 mitogen-activated protein kinase. This occurs via a mechanism that involves the LPP1-induced down-regulation of typical protein kinase C isoform(s), which are normally required for platelet-derived growth factor-induced activation of p42/p44 mitogen-activated protein kinase and migration Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.4 overexpression in HEK-293 cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.4 additional information LPP-1 overexpression mutant shows inhibited cell migration of embryonic fibroblasts by reduction of lysophosphatidic acid- and platelet-derived-growth-factor-induced activation of the p42/p44 MAPK pathway, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.4 membrane integral Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.4 lysophosphatidic acid + H2O Mus musculus
-
 monoacylglycerol + phosphate
-
 ?
3.1.3.4 additional information Mus musculus LPP is involved in regulation of bioactive lipids acting in signalling pathways, LPP-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration via the p42/p44 MAPK pathway, overview ?
-
 ?
3.1.3.4 sphingosine 1-phosphate + H2O Mus musculus
-
 sphingosine + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Mus musculus
-
-
-
3.1.3.4 Mus musculus
-
 isozyme LPP-1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.4 fibroblast
-
 Mus musculus
-
3.1.3.4 fibroblast embryonic, derived from LPP-1 overexpression mutant and wild-type mice Mus musculus
-
3.1.3.4 MEF cell
-
 Mus musculus
-
3.1.3.4 MEF cell embryonic fibroblast cell line Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 glycerophosphate + H2O
-
 Mus musculus glycerol + phosphate
-
 ?
3.1.3.4 lysophosphatidic acid + H2O
-
 Mus musculus monoacylglycerol + phosphate
-
 ?
3.1.3.4 additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, LPP-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration via the p42/p44 MAPK pathway, overview Mus musculus ?
-
 ?
3.1.3.4 sphingosine 1-phosphate + H2O
-
 Mus musculus sphingosine + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.4 lipid phosphate phosphatase
-
 Mus musculus
3.1.3.4 lipid phosphate phosphatase-1
-
 Mus musculus
3.1.3.4 LPP
-
 Mus musculus
3.1.3.4 LPP1
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.4 30
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.4 6.5
-
 assay at Mus musculus