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Literature summary extracted from

  • Crawford, R.M.; Treharne, K.J.; Best, O.G.; Muimo, R.; Riemen, C.E.; Mehta, A
    A novel physical and functional association between nucleoside diphosphate kinase A and AMP-activated protein kinase alpha1 in liver and lung (2005), Biochem. J., 392, 201-209.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.31 expression of His-tagged isozymes alpha1 and alpha2 in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.31 additional information complex formation between isozyme alpha1 and NDPK-H1 inhibits the AMPK activity, inhibition by NDPK is reduced by addition of ADP or GTP, overview Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.31 cytosol
-
 Homo sapiens 5829
-
2.7.11.31 cytosol
-
 Rattus norvegicus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.31 180000
-
 x * 180000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.31 ATP + acetyl-CoA carboxylase Homo sapiens
-
 ADP + phosphorylated acetyl-CoA carboxylase
-
 ?
2.7.11.31 ATP + acetyl-CoA carboxylase 1 Rattus norvegicus
-
 ADP + phosphorylated acetyl-CoA carboxylase 1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.31 Homo sapiens
-
 isozymes alpha1 and alpha2
-
2.7.11.31 Rattus norvegicus
-
 isozymes alpha1 and alpha2
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.31 isozymes alpha1 and alpha2 from liver homogenates by subcellular fractionation and immunoprecipitation Rattus norvegicus
2.7.11.31 recombinant His-tagged isozymes alpha1 and alpha2 from Escherichia coli by nickel affinity chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.31 liver
-
 Homo sapiens
-
2.7.11.31 liver
-
 Rattus norvegicus
-
2.7.11.31 lung
-
 Homo sapiens
-
2.7.11.31 lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.31 ATP + acetyl-CoA carboxylase
-
 Homo sapiens ADP + phosphorylated acetyl-CoA carboxylase
-
 ?
2.7.11.31 ATP + acetyl-CoA carboxylase 1
-
 Rattus norvegicus ADP + phosphorylated acetyl-CoA carboxylase 1
-
 ?
2.7.11.31 ATP + HMRSAMSGLHLVKRR acetyl-CoA carboxylase-derived synthetic peptide substrate Homo sapiens ADP + ?
-
 ?
2.7.11.31 ATP + HMRSAMSGLHLVKRR acetyl-CoA carboxylase-derived synthetic peptide substrate Rattus norvegicus ADP + ?
-
 ?
2.7.11.31 additional information the enzyme is regulated by the nucleoside diphosphate kinase, complex formation in vivo, e.g. between isozyme alpha1 and NDPK-H1, inhibits the enzyme, overview Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.31 ? x * 180000, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.31 AMP-activated protein kinase alpha
-
 Rattus norvegicus
2.7.11.31 AMP-activated protein kinase alpha1
-
 Homo sapiens
2.7.11.31 AMPK
-
 Rattus norvegicus
2.7.11.31 AMPK1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.31 30
-
 assay at Homo sapiens
2.7.11.31 30
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.31 ATP
-
 Homo sapiens
2.7.11.31 ATP
-
 Rattus norvegicus