EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.11.31 | expression of His-tagged isozymes alpha1 and alpha2 in Escherichia coli | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.31 | additional information | complex formation between isozyme alpha1 and NDPK-H1 inhibits the AMPK activity, inhibition by NDPK is reduced by addition of ADP or GTP, overview | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.11.31 | cytosol | - |
Homo sapiens | 5829 | - |
2.7.11.31 | cytosol | - |
Rattus norvegicus | 5829 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.7.11.31 | 180000 | - |
x * 180000, SDS-PAGE | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.31 | ATP + acetyl-CoA carboxylase | Homo sapiens | - |
ADP + phosphorylated acetyl-CoA carboxylase | - |
? | |
2.7.11.31 | ATP + acetyl-CoA carboxylase 1 | Rattus norvegicus | - |
ADP + phosphorylated acetyl-CoA carboxylase 1 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.31 | Homo sapiens | - |
isozymes alpha1 and alpha2 | - |
2.7.11.31 | Rattus norvegicus | - |
isozymes alpha1 and alpha2 | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.11.31 | isozymes alpha1 and alpha2 from liver homogenates by subcellular fractionation and immunoprecipitation | Rattus norvegicus |
2.7.11.31 | recombinant His-tagged isozymes alpha1 and alpha2 from Escherichia coli by nickel affinity chromatography | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.31 | liver | - |
Homo sapiens | - |
2.7.11.31 | liver | - |
Rattus norvegicus | - |
2.7.11.31 | lung | - |
Homo sapiens | - |
2.7.11.31 | lung | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.31 | ATP + acetyl-CoA carboxylase | - |
Homo sapiens | ADP + phosphorylated acetyl-CoA carboxylase | - |
? | |
2.7.11.31 | ATP + acetyl-CoA carboxylase 1 | - |
Rattus norvegicus | ADP + phosphorylated acetyl-CoA carboxylase 1 | - |
? | |
2.7.11.31 | ATP + HMRSAMSGLHLVKRR | acetyl-CoA carboxylase-derived synthetic peptide substrate | Homo sapiens | ADP + ? | - |
? | |
2.7.11.31 | ATP + HMRSAMSGLHLVKRR | acetyl-CoA carboxylase-derived synthetic peptide substrate | Rattus norvegicus | ADP + ? | - |
? | |
2.7.11.31 | additional information | the enzyme is regulated by the nucleoside diphosphate kinase, complex formation in vivo, e.g. between isozyme alpha1 and NDPK-H1, inhibits the enzyme, overview | Rattus norvegicus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.11.31 | ? | x * 180000, SDS-PAGE | Rattus norvegicus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.31 | AMP-activated protein kinase alpha | - |
Rattus norvegicus |
2.7.11.31 | AMP-activated protein kinase alpha1 | - |
Homo sapiens |
2.7.11.31 | AMPK | - |
Rattus norvegicus |
2.7.11.31 | AMPK1 | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.11.31 | 30 | - |
assay at | Homo sapiens |
2.7.11.31 | 30 | - |
assay at | Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.31 | ATP | - |
Homo sapiens | |
2.7.11.31 | ATP | - |
Rattus norvegicus |