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Literature summary extracted from

  • Napirei, M.; Wulf, S.; Eulitz, D.; Mannherz, H.G.; Kloeckl, T.
    Comparative characterization of rat deoxyribonuclease 1 (Dnase1) and murine deoxyribonuclease 1-like 3 (Dnase1l3) (2005), Biochem. J., 389, 355-364.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.21.1 expression in NIH-3T3 fibroblasts Mus musculus
3.1.21.1 expression in NIH-3T3 fibroblasts Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.21.1 EDTA
-
 Mus musculus
3.1.21.1 EDTA
-
 Rattus norvegicus
3.1.21.1 EGTA
-
 Mus musculus
3.1.21.1 EGTA
-
 Rattus norvegicus
3.1.21.1 G-actin
-
 Rattus norvegicus
3.1.21.1 heparin
-
 Mus musculus
3.1.21.1 Zn2+
-
 Mus musculus
3.1.21.1 Zn2+
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.21.1 endoplasmic reticulum
-
 Mus musculus 5783
-
3.1.21.1 endoplasmic reticulum
-
 Rattus norvegicus 5783
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.21.1 Ca2+ required Mus musculus
3.1.21.1 Ca2+ required Rattus norvegicus
3.1.21.1 Mg2+ either Mg2+ or Mn2+ is required in addition to Ca2+ Mus musculus
3.1.21.1 Mg2+ either Mg2+ or Mn2+ is required in addition to Ca2+ Rattus norvegicus
3.1.21.1 Mn2+ either Mg2+ or Mn2+ is required in addition to Ca2+ Mus musculus
3.1.21.1 Mn2+ either Mg2+ or Mn2+ is required in addition to Ca2+ Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.21.1 Mus musculus
-
-
-
3.1.21.1 Rattus norvegicus P21704
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.21.1 double-stranded DNA + H2O high activity on plasmid DNA, weak activity on nuclear DNA Rattus norvegicus 5'-phosphooligonucleotides + ?
-
 ?
3.1.21.1 double-stranded DNA + H2O low activity on plasmid DNA, high activity on nuclear DNA Mus musculus 5'-phosphooligonucleotides + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.21.1 deoxyribonuclease 1
-
 Rattus norvegicus
3.1.21.1 deoxyribonuclease 1-like 3
-
 Mus musculus
3.1.21.1 Dnase1
-
 Rattus norvegicus