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Literature summary extracted from

  • Franco, R.; Bai, G.; Prosinecki, V.; Abrunhosa, F.; Ferreira, G.C.; Bastos, M.
    Porphyrin-substrate binding to murine ferrochelatase: effect on the thermal stability of the enzyme (2005), Biochem. J., 386, 599-605.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.98.1.1 expression in Escherichia coli, wild-type and mutants E289Q and E289A Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
4.98.1.1 E289A enhanced protein stability Mus musculus
4.98.1.1 E289Q enhanced protein stability Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.98.1.1 protoporphyrin + Fe2+ Mus musculus
-
 protoheme + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.98.1.1 Mus musculus P22315
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.98.1.1
-
 Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.98.1.1 mesoporphyrin + Fe2+ pH 8.0 Mus musculus mesoheme
-
 ?
4.98.1.1 protoporphyrin + Fe2+
-
 Mus musculus protoheme + H+
-
 ?
4.98.1.1 protoporphyrin IX + Zn2+
-
 Mus musculus Zn-protoporphyrin IX
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.98.1.1 ferrochelatase
-
 Mus musculus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
4.98.1.1 55.8
-
 Tm, wild-type in phosphate buffer Mus musculus
4.98.1.1 56
-
 Tm, wild-type in bicine buffer Mus musculus
4.98.1.1 57.5
-
 Tm, mutant E289A Mus musculus
4.98.1.1 61
-
 Tm, mutant E289Q Mus musculus