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Literature summary extracted from

  • Zhao, Y.; Usatyuk, P.V.; Cummings, R.; Saatian, B.; He, D.; Watkins, T.; Morris, A.; Spannhake, E.W.; Brindley, D.; Natarajan, V.
    Lipid phosphate phosphatase-1 regulates the lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells (2005), Biochem. J., 385, 493-502.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.106 expression of myc-tagged wild-type human and mouse LPP-1 isozyme or Myc-tagged human and mouse LPP-1 mutant R217K in primary bronchial epithelial cells Homo sapiens
3.1.3.106 expression of myc-tagged wild-type LPP-1 isozyme or Myc-tagged recombinant LPP-1 mutant R217K in human primary bronchial epithelial cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.106 R217K adenoviral construction of an inactive isozyme LPP-1 mutant Homo sapiens
3.1.3.106 R217K adenoviral construction of an isozyme LPP-1 mouse mutant showing partially attenuated LPA-induced interleukin-8 secretion without alteration of LPA-induced changes in intracellular Ca2+ concentration Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.3.106 plasma membrane outside surface, ecto-enzyme Mus musculus 5886
-
3.1.3.106 plasma membrane outside surface, ecto-enzyme Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.106 lysophosphatidic acid + H2O Mus musculus
-
 monoacylglycerol + phosphate
-
 ?
3.1.3.106 lysophosphatidic acid + H2O Homo sapiens
-
 monoacylglycerol + phosphate
-
 ?
3.1.3.106 additional information Mus musculus LPP is involved in regulation of bioactive lipids acting in signalling pathways, overview, LPP-1 regulates the lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in epithelial cells ?
-
 ?
3.1.3.106 additional information Homo sapiens LPP is involved in regulation of bioactive lipids acting in signalling pathways, overview, LPP-1 regulates the lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.106 Homo sapiens
-
-
-
3.1.3.106 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.106 epithelial cell
-
 Mus musculus
-
3.1.3.106 HBEpC cell primary bronchial epithelial cells Homo sapiens
-
3.1.3.106 lung
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.106 additional information
-
 recombinant activity of wild-type and mutant enzymes in transformed cells Mus musculus
3.1.3.106 additional information
-
 recombinant activity of wild-type and mutant enzymes in transformed cells Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.106 1-oleoyl-2-lyso-sn-glycerol 3-phosphate + H2O
-
 Mus musculus 1-oleoyl-sn-glycerol + phosphate
-
 ?
3.1.3.106 1-oleoyl-2-lyso-sn-glycerol 3-phosphate + H2O
-
 Homo sapiens 1-oleoyl-sn-glycerol + phosphate
-
 ?
3.1.3.106 lysophosphatidic acid + H2O
-
 Mus musculus monoacylglycerol + phosphate
-
 ?
3.1.3.106 lysophosphatidic acid + H2O
-
 Homo sapiens monoacylglycerol + phosphate
-
 ?
3.1.3.106 additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, overview, LPP-1 regulates the lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in epithelial cells Mus musculus ?
-
 ?
3.1.3.106 additional information LPP is involved in regulation of bioactive lipids acting in signalling pathways, overview, LPP-1 regulates the lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.106 lipid phosphate phosphatase
-
 Mus musculus
3.1.3.106 lipid phosphate phosphatase
-
 Homo sapiens
3.1.3.106 LPP
-
 Mus musculus
3.1.3.106 LPP
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.106 37
-
 assay at Mus musculus
3.1.3.106 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.106 7.5
-
 assay at Mus musculus
3.1.3.106 7.5
-
 assay at Homo sapiens