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Literature summary extracted from

  • Rider, M.H.; Bertrand, L.; Vertommen, D.; Michels, P.A.; Rousseau, G.G.; Hue, L.
    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis (2004), Biochem. J., 381, 561-579.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.46 genes PFKFB1-4, chromosomal localization of tissue-specific isozymes, phylogenetic analysis, overview, transcriptional control of isozymes, overview Homo sapiens
3.1.3.46 genes PFKFB1-4, chromosomal localization of tissue-specific isozymes, phylogenetic analysis, overview, transcriptional control of isozymes, overview Rattus norvegicus
3.1.3.46 phylogenetic analysis Schizosaccharomyces pombe
3.1.3.46 phylogenetic analysis Leishmania major
3.1.3.46 phylogenetic analysis Arabidopsis thaliana
3.1.3.46 phylogenetic analysis Drosophila melanogaster
3.1.3.46 phylogenetic analysis, transcriptional control of isozymes, overview Bos taurus
3.1.3.46 phylogenetic analysis, transcriptional control of isozymes, overview Mus musculus
3.1.3.46 possible evolution of the proteobacterial gene by horizontal gene transfer from an eukaryote, phylogenetic analysis Desulfovibrio desulfuricans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Schizosaccharomyces pombe
-
 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Desulfovibrio desulfuricans
-
 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Leishmania major
-
 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Arabidopsis thaliana
-
 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Drosophila melanogaster
-
 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Homo sapiens metabolic regulation of isozyme PFKFB1 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Bos taurus metabolic regulation of isozyme PFKFB1 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Rattus norvegicus metabolic regulation of isozyme PFKFB1 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Homo sapiens metabolic regulation of isozyme PFKFB2 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Rattus norvegicus metabolic regulation of isozyme PFKFB2 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Mus musculus metabolic regulation of isozyme PFKFB2 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Bos taurus metabolic regulation of isozyme PFKFB2 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Homo sapiens metabolic regulation of isozyme PFKFB3 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Bos taurus metabolic regulation of isozyme PFKFB3 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Mus musculus metabolic regulation of isozyme PFKFB3 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Homo sapiens metabolic regulation of isozyme PFKFB4 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O Rattus norvegicus metabolic regulation of isozyme PFKFB4 D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 additional information Schizosaccharomyces pombe study of bifunctional enzyme evolution ?
-
 ?
3.1.3.46 additional information Desulfovibrio desulfuricans study of bifunctional enzyme evolution ?
-
 ?
3.1.3.46 additional information Leishmania major study of bifunctional enzyme evolution ?
-
 ?
3.1.3.46 additional information Arabidopsis thaliana study of bifunctional enzyme evolution ?
-
 ?
3.1.3.46 additional information Homo sapiens study of bifunctional enzyme evolution ?
-
 ?
3.1.3.46 additional information Rattus norvegicus study of bifunctional enzyme evolution ?
-
 ?
3.1.3.46 additional information Bos taurus study of bifunctional enzyme evolution ?
-
 ?
3.1.3.46 additional information Mus musculus study of bifunctional enzyme evolution ?
-
 ?
3.1.3.46 additional information Drosophila melanogaster study of bifunctional enzyme evolution ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.46 Arabidopsis thaliana Q9MB58
-
-
3.1.3.46 Bos taurus P26285 heart isozyme PFKFB2; genes PFKFB1-4, four isozymes
-
3.1.3.46 Bos taurus P49872 liver isozyme PFKFB1; genes PFKFB1-4, four isozymes
-
3.1.3.46 Bos taurus Q28901 brain isozyme PFKFB3; genes PFKFB1-4, four isozymes
-
3.1.3.46 Desulfovibrio desulfuricans
-
-
-
3.1.3.46 Drosophila melanogaster Q9VWH7 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase long form; gene Pfrx
-
3.1.3.46 Homo sapiens O60825 heart isozyme PFKFB2; genes PFKFB1-4, four isozymes
-
3.1.3.46 Homo sapiens P16118 liver isozyme PFKFB1; genes PFKFB1-4, four isozymes
-
3.1.3.46 Homo sapiens Q16875 brain/placenta isozyme PFKFB3; genes PFKFB1-4, four isozymes
-
3.1.3.46 Homo sapiens Q16877 testis isozyme PFKFB4; genes PFKFB1-4, four isozymes
-
3.1.3.46 Leishmania major
-
 This UniProt-ID has been deleted
-
3.1.3.46 Mus musculus P70265 heart isozyme PFKFB2; genes PFKFB1-4, four isozymes
-
3.1.3.46 Mus musculus Q9ESY2 inducible isozyme PFKFB3; genes PFKFB1-4, four isozymes
-
3.1.3.46 Rattus norvegicus O35552 brain isozyme PFKFB2; genes PFKFB1-4, four isozymes
-
3.1.3.46 Rattus norvegicus P07953 liver isozyme PFKFB1; genes PFKFB1-4, four isozymes
-
3.1.3.46 Rattus norvegicus P25114 testis isozyme PFKFB4; genes PFKFB1-4, four isozymes
-
3.1.3.46 Rattus norvegicus Q9JJH5 heart isozyme PFKFB2; genes PFKFB1-4, four isozymes
-
3.1.3.46 Schizosaccharomyces pombe
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview Schizosaccharomyces pombe
a
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview Desulfovibrio desulfuricans
a
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview Leishmania major
a
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview Arabidopsis thaliana
a
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview Homo sapiens
a
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview Rattus norvegicus
a
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview Bos taurus
a
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview Mus musculus
a
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate FBPase performs a reaction following a classical ping pong mechanism with formation of a phosphoryl-enzyme intermediate on a histidine residue located in an Arg-His-Gly triad, catalytic site structure, overview Drosophila melanogaster
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.46 brain isozyme PFKFB3 Homo sapiens
-
3.1.3.46 brain isozyme PFKFB3 Bos taurus
-
3.1.3.46 brain specific isozyme PFKFB2 Rattus norvegicus
-
3.1.3.46 heart isozyme PFKFB2 Homo sapiens
-
3.1.3.46 heart isozyme PFKFB2 Mus musculus
-
3.1.3.46 heart isozyme PFKFB2 Bos taurus
-
3.1.3.46 heart specific isozyme PFKFB2 Rattus norvegicus
-
3.1.3.46 liver isozyme PFKFB1 Homo sapiens
-
3.1.3.46 liver isozyme PFKFB1 Bos taurus
-
3.1.3.46 liver specific isozyme PFKFB1 Rattus norvegicus
-
3.1.3.46 additional information tissue-specific expression of the different isozymes, overview Homo sapiens
-
3.1.3.46 additional information tissue-specific expression of the different isozymes, overview Rattus norvegicus
-
3.1.3.46 additional information tissue-specific expression of the different isozymes, overview Bos taurus
-
3.1.3.46 additional information tissue-specific expression of the different isozymes, overview Mus musculus
-
3.1.3.46 placenta inducible isozyme PFKFB3 Mus musculus
-
3.1.3.46 placenta isozyme PFKFB3 Homo sapiens
-
3.1.3.46 placenta isozyme PFKFB3 Bos taurus
-
3.1.3.46 placenta specific isozyme PFKFB2 Rattus norvegicus
-
3.1.3.46 testis specific isozyme PFKFB4 Homo sapiens
-
3.1.3.46 testis specific isozyme PFKFB4 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O
-
 Schizosaccharomyces pombe D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O
-
 Desulfovibrio desulfuricans D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O
-
 Leishmania major D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O
-
 Arabidopsis thaliana D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O
-
 Homo sapiens D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O
-
 Rattus norvegicus D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O
-
 Bos taurus D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O
-
 Mus musculus D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O
-
 Drosophila melanogaster D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O metabolic regulation of isozyme PFKFB1 Homo sapiens D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O metabolic regulation of isozyme PFKFB1 Bos taurus D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O metabolic regulation of isozyme PFKFB1 Rattus norvegicus D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O metabolic regulation of isozyme PFKFB2 Homo sapiens D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O metabolic regulation of isozyme PFKFB2 Rattus norvegicus D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O metabolic regulation of isozyme PFKFB2 Mus musculus D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O metabolic regulation of isozyme PFKFB2 Bos taurus D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O metabolic regulation of isozyme PFKFB3 Homo sapiens D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O metabolic regulation of isozyme PFKFB3 Bos taurus D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O metabolic regulation of isozyme PFKFB3 Mus musculus D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O metabolic regulation of isozyme PFKFB4 Homo sapiens D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 beta-D-fructose 2,6-bisphosphate + H2O metabolic regulation of isozyme PFKFB4 Rattus norvegicus D-fructose 6-phosphate + phosphate
-
 ?
3.1.3.46 additional information study of bifunctional enzyme evolution Schizosaccharomyces pombe ?
-
 ?
3.1.3.46 additional information study of bifunctional enzyme evolution Desulfovibrio desulfuricans ?
-
 ?
3.1.3.46 additional information study of bifunctional enzyme evolution Leishmania major ?
-
 ?
3.1.3.46 additional information study of bifunctional enzyme evolution Arabidopsis thaliana ?
-
 ?
3.1.3.46 additional information study of bifunctional enzyme evolution Homo sapiens ?
-
 ?
3.1.3.46 additional information study of bifunctional enzyme evolution Rattus norvegicus ?
-
 ?
3.1.3.46 additional information study of bifunctional enzyme evolution Bos taurus ?
-
 ?
3.1.3.46 additional information study of bifunctional enzyme evolution Mus musculus ?
-
 ?
3.1.3.46 additional information study of bifunctional enzyme evolution Drosophila melanogaster ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.3.46 dimer homodimeric bifunctional enzyme Schizosaccharomyces pombe
3.1.3.46 dimer homodimeric bifunctional enzyme Desulfovibrio desulfuricans
3.1.3.46 dimer homodimeric bifunctional enzyme Leishmania major
3.1.3.46 dimer homodimeric bifunctional enzyme Arabidopsis thaliana
3.1.3.46 dimer homodimeric bifunctional enzyme Homo sapiens
3.1.3.46 dimer homodimeric bifunctional enzyme Rattus norvegicus
3.1.3.46 dimer homodimeric bifunctional enzyme Bos taurus
3.1.3.46 dimer homodimeric bifunctional enzyme Mus musculus
3.1.3.46 dimer homodimeric bifunctional enzyme Drosophila melanogaster
3.1.3.46 More domain organization of the bifunctional enzyme, head-to-head structure of the two subunits of the bifunctional enzyme, overview Schizosaccharomyces pombe
3.1.3.46 More domain organization of the bifunctional enzyme, head-to-head structure of the two subunits of the bifunctional enzyme, overview Leishmania major
3.1.3.46 More domain organization of the bifunctional enzyme, head-to-head structure of the two subunits of the bifunctional enzyme, overview Arabidopsis thaliana
3.1.3.46 More domain organization of the bifunctional enzyme, head-to-head structure of the two subunits of the bifunctional enzyme, overview Homo sapiens
3.1.3.46 More domain organization of the bifunctional enzyme, head-to-head structure of the two subunits of the bifunctional enzyme, overview Rattus norvegicus
3.1.3.46 More domain organization of the bifunctional enzyme, head-to-head structure of the two subunits of the bifunctional enzyme, overview Bos taurus
3.1.3.46 More domain organization of the bifunctional enzyme, head-to-head structure of the two subunits of the bifunctional enzyme, overview Drosophila melanogaster
3.1.3.46 More head-to-head structure of the two subunits of the bifunctional enzyme, overview Desulfovibrio desulfuricans
3.1.3.46 More head-to-head structure of the two subunits of the bifunctional enzyme, overview Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.1.3.46 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
 Schizosaccharomyces pombe
3.1.3.46 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
 Desulfovibrio desulfuricans
3.1.3.46 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
 Leishmania major
3.1.3.46 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
 Arabidopsis thaliana
3.1.3.46 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
 Homo sapiens
3.1.3.46 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
 Rattus norvegicus
3.1.3.46 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
 Bos taurus
3.1.3.46 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
 Mus musculus
3.1.3.46 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
 Drosophila melanogaster
3.1.3.46 F2KP
-
 Arabidopsis thaliana
3.1.3.46 FBPase-2
-
 Schizosaccharomyces pombe
3.1.3.46 FBPase-2
-
 Desulfovibrio desulfuricans
3.1.3.46 FBPase-2
-
 Leishmania major
3.1.3.46 FBPase-2
-
 Arabidopsis thaliana
3.1.3.46 FBPase-2
-
 Homo sapiens
3.1.3.46 FBPase-2
-
 Rattus norvegicus
3.1.3.46 FBPase-2
-
 Bos taurus
3.1.3.46 FBPase-2
-
 Mus musculus
3.1.3.46 FBPase-2
-
 Drosophila melanogaster
3.1.3.46 fructose-2,6-bisphosphatase
-
 Schizosaccharomyces pombe
3.1.3.46 fructose-2,6-bisphosphatase
-
 Desulfovibrio desulfuricans
3.1.3.46 fructose-2,6-bisphosphatase
-
 Leishmania major
3.1.3.46 fructose-2,6-bisphosphatase
-
 Arabidopsis thaliana
3.1.3.46 fructose-2,6-bisphosphatase
-
 Homo sapiens
3.1.3.46 fructose-2,6-bisphosphatase
-
 Rattus norvegicus
3.1.3.46 fructose-2,6-bisphosphatase
-
 Bos taurus
3.1.3.46 fructose-2,6-bisphosphatase
-
 Mus musculus
3.1.3.46 fructose-2,6-bisphosphatase
-
 Drosophila melanogaster
3.1.3.46 Lm1
-
 Leishmania major
3.1.3.46 More bifunctional enzyme, cf. EC 2.7.1.105 Schizosaccharomyces pombe
3.1.3.46 More bifunctional enzyme, cf. EC 2.7.1.105 Desulfovibrio desulfuricans
3.1.3.46 More bifunctional enzyme, cf. EC 2.7.1.105 Leishmania major
3.1.3.46 More bifunctional enzyme, cf. EC 2.7.1.105 Arabidopsis thaliana
3.1.3.46 More bifunctional enzyme, cf. EC 2.7.1.105 Homo sapiens
3.1.3.46 More bifunctional enzyme, cf. EC 2.7.1.105 Rattus norvegicus
3.1.3.46 More bifunctional enzyme, cf. EC 2.7.1.105 Bos taurus
3.1.3.46 More bifunctional enzyme, cf. EC 2.7.1.105 Mus musculus
3.1.3.46 More bifunctional enzyme, cf. EC 2.7.1.105 Drosophila melanogaster
3.1.3.46 PFK-2/FBPase-2
-
 Schizosaccharomyces pombe
3.1.3.46 PFK-2/FBPase-2
-
 Desulfovibrio desulfuricans
3.1.3.46 PFK-2/FBPase-2
-
 Leishmania major
3.1.3.46 PFK-2/FBPase-2
-
 Arabidopsis thaliana
3.1.3.46 PFK-2/FBPase-2
-
 Homo sapiens
3.1.3.46 PFK-2/FBPase-2
-
 Rattus norvegicus
3.1.3.46 PFK-2/FBPase-2
-
 Bos taurus
3.1.3.46 PFK-2/FBPase-2
-
 Mus musculus
3.1.3.46 PFK-2/FBPase-2
-
 Drosophila melanogaster
3.1.3.46 Pfk26
-
 Schizosaccharomyces pombe
3.1.3.46 Pfk27
-
 Schizosaccharomyces pombe
3.1.3.46 RH2K
-
 Rattus norvegicus