EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.52 | 5-hydroxy-D-tryptophan | 0.1 mM, 26% inhibition of cleavage of D-tryptophan, 29% inhibition of cleavage of L-tryptophan | Mus musculus | |
1.13.11.52 | 5-hydroxy-L-tryptophan | 0.1 mM, 40% inhibition of cleavage of D-tryptophan, 53% inhibition of cleavage of L-tryptophan | Mus musculus | |
1.13.11.52 | indole-3-acetic acid | 1 mM, 19% inhibition of cleavage of D-tryptophan, 27% inhibition of cleavage of L-tryptophan | Mus musculus | |
1.13.11.52 | indole-3-acrylic acid | competitive inhibitor | Mus musculus | |
1.13.11.52 | iodoacetic acid | 1 mM, 12% inhibition of cleavage of D-tryptophan, 7% inhibition of cleavage of L-tryptophan | Mus musculus | |
1.13.11.52 | KCN | 0.01 mM, 39% inhibition of cleavage of D-tryptophan, 48% inhibition of cleavage of L-tryptophan | Mus musculus | |
1.13.11.52 | additional information | not inhibited by superoxide dismutase | Mus musculus | |
1.13.11.52 | N-ethylmaleimide | 1 mM, 58% inhibition of cleavage of D-tryptophan, 45% inhibition of cleavage of L-tryptophan | Mus musculus | |
1.13.11.52 | NaN3 | 10 mM, 33% inhibition of cleavage of D-tryptophan, 32% inhibition of cleavage of L-tryptophan | Mus musculus | |
1.13.11.52 | serotonin | 1 mM, 36% inhibition of cleavage of D-tryptophan, 37% inhibition of cleavage of L-tryptophan | Mus musculus | |
1.13.11.52 | Tiron | 10 mM, 2% inhibition of cleavage of D-tryptophan, 6% inhibition of cleavage of L-tryptophan | Mus musculus | |
1.13.11.52 | tryptamine | 0.1 mM, 16% inhibition of cleavage of D-tryptophan, 11% inhibition of cleavage of L-tryptophan | Mus musculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.13.11.52 | 0.21 | - |
L-tryptophan | - |
Mus musculus | |
1.13.11.52 | 0.96 | - |
D-tryptophan | - |
Mus musculus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.13.11.52 | 150000 | - |
alpha2beta2 subunit | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.13.11.52 | Bos taurus | - |
- |
- |
1.13.11.52 | Capra hircus | - |
- |
- |
1.13.11.52 | Homo sapiens | - |
- |
- |
1.13.11.52 | Macaca fuscata fuscata | - |
- |
- |
1.13.11.52 | Mus musculus | - |
- |
- |
1.13.11.52 | Oryctolagus cuniculus | - |
- |
- |
1.13.11.52 | Pseudomonas fluorescens | - |
- |
- |
1.13.11.52 | Rattus norvegicus | - |
Sprague Dawley | - |
1.13.11.52 | Sus scrofa | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.13.11.52 | ammonium sulfate precipitation, hydroxyapatite column chromatography (two times), gel filtration, DEAE cellulose column chromatography, third hydroxyapatite column chromatography, Sephadex G-200 gel filtration, second DEAE cellulose column chromatography | Mus musculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.13.11.52 | liver | - |
Mus musculus | - |
1.13.11.52 | liver | - |
Homo sapiens | - |
1.13.11.52 | liver | - |
Rattus norvegicus | - |
1.13.11.52 | liver | - |
Sus scrofa | - |
1.13.11.52 | liver | - |
Bos taurus | - |
1.13.11.52 | liver | - |
Oryctolagus cuniculus | - |
1.13.11.52 | liver | - |
Capra hircus | - |
1.13.11.52 | liver | - |
Macaca fuscata fuscata | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.13.11.52 | 0.55 | - |
25°C, 50 mM HEPES/NaOH (pH 7.3), 5 mM D-tryptophan 0.01 mM methylene blue, 5 mM ascorbic acid, 0.001 mM catalase | Mus musculus |
1.13.11.52 | 2.13 | - |
25°C, 50 mM HEPES/NaOH (pH 7.3), 2 mM L-tryptophan 0.01 mM methylene blue, 5 mM ascorbic acid, 0.001 mM catalase | Mus musculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.52 | D-tryptophan + O2 | - |
Mus musculus | N-formyl-D-kynurenine | - |
? | |
1.13.11.52 | L-tryptophan + O2 | - |
Mus musculus | N-formyl-L-kynurenine | - |
? | |
1.13.11.52 | L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? | |
1.13.11.52 | L-tryptophan + O2 | - |
Rattus norvegicus | N-formyl-L-kynurenine | - |
? | |
1.13.11.52 | L-tryptophan + O2 | - |
Sus scrofa | N-formyl-L-kynurenine | - |
? | |
1.13.11.52 | L-tryptophan + O2 | - |
Bos taurus | N-formyl-L-kynurenine | - |
? | |
1.13.11.52 | L-tryptophan + O2 | - |
Oryctolagus cuniculus | N-formyl-L-kynurenine | - |
? | |
1.13.11.52 | L-tryptophan + O2 | - |
Pseudomonas fluorescens | N-formyl-L-kynurenine | - |
? | |
1.13.11.52 | L-tryptophan + O2 | - |
Capra hircus | N-formyl-L-kynurenine | - |
? | |
1.13.11.52 | L-tryptophan + O2 | - |
Macaca fuscata fuscata | N-formyl-L-kynurenine | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.13.11.52 | 7.3 | - |
25°C | Mus musculus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.13.11.52 | 0.0045 | - |
indole-3-acrylic acid | against L-tryptophan | Mus musculus | |
1.13.11.52 | 0.0068 | - |
indole-3-acrylic acid | against D-tryptophan | Mus musculus |