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Literature summary extracted from

  • Shim, B.S.; Kang, B.H.; Hong, Y.K.; Kim, H.K.; Lee, I.H.; Lee, S.Y.; Lee, Y.J.; Lee, S.K.; Joe, Y.A.
    The kringle domain of tissue-type plasminogen activator inhibits in vivo tumor growth (2005), Biochem. Biophys. Res. Commun., 327, 1155-1162.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.68 medicine the kringle domain of tissue-type plasminogen activator inhibits in vivo tumor growth by suppression of angiogenesis without interfering with fibrinolysis Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.68 expression in Escherichia coli and Saccharomyces cerevisiae Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.68 19950
-
 monomer, kringle domain of tissue-type plasminogen activator, calculated from amino acid sequence Homo sapiens
3.4.21.68 21590
-
 monomer, kringle domain of tissue-type plasminogen activator, glycosylated, MALDI analysis Homo sapiens
3.4.21.68 23940
-
 monomer, kringle domain of tissue-type plasminogen activator, glycosylated, MALDI analysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.68 plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.68 Homo sapiens P00750
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.68 A-549 cell
-
 Homo sapiens
-
3.4.21.68 DLD-1 cell
-
 Homo sapiens
-
3.4.21.68 HCT-116 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.68 plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?
3.4.21.68 plasminogen + H2O 37°C, pH 7.6 Homo sapiens plasmin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.68 t-PA
-
 Homo sapiens
3.4.21.68 Tissue-type plasminogen activator
-
 Homo sapiens