Literature summary extracted from

Schroder, O.; Sjostrom, M.; Qiu, H.; Stein, J.; Jakobsson, P.J.; Haeggstrom, J.Z.
Molecular and catalytic properties of three rat leukotriene C4 synthase homologs (2003), Biochem. Biophys. Res. Commun., 312, 271-276.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
4.4.1.20	expression in Spodoptera frugiperda	Rattus norvegicus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
4.4.1.20	cysteinyl-leukotriene	-	Rattus norvegicus
4.4.1.20	MK-886	-	Rattus norvegicus

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
4.4.1.20	0.0188	-	leukotriene A4 free acid	4°C, pH 7.35	Rattus norvegicus
4.4.1.20	0.0198	-	leukotriene A4 methyl ester	4°C, pH 7.35	Rattus norvegicus

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
4.4.1.20	16800	-	calculated from amino acid sequence	Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
4.4.1.20	leukotriene C4	Rattus norvegicus	-	leukotriene A4 + glutathione	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.4.1.20	Rattus norvegicus	Q925U2	-	-

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
4.4.1.20	0.0562	-	with leukotriene A4 free acid as substrate	Rattus norvegicus
4.4.1.20	0.0813	-	with leukotriene A4 methyl ester as substrate	Rattus norvegicus

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.4.1.20	leukotriene A4 + glutathione	free acid, 4°C, pH 7.35	Rattus norvegicus	leukotriene C4	-	r
4.4.1.20	leukotriene A4 free acid + glutathione	-	Rattus norvegicus	leukotriene C4	-	?
4.4.1.20	leukotriene A4 methyl ester + glutathione	4°C, pH 7.35	Rattus norvegicus	leukotriene C4 methyl ester	-	r
4.4.1.20	leukotriene C4	-	Rattus norvegicus	leukotriene A4 + glutathione	-	r

Synonyms

EC Number	Synonyms	Comment	Organism
4.4.1.20	leukotriene C4 synthase	-	Rattus norvegicus
4.4.1.20	LTC4S	-	Rattus norvegicus

pI Value

EC Number	Organism	Comment	pI Value Maximum	pI Value
4.4.1.20	Rattus norvegicus	calculated from amino acid sequence	-	9.69

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Release 2023.1 (January 2023)