BRENDA - Enzyme Database

A protective association between catalase and isocitrate lyase in peroxisomes

Yanik, T.; Donaldson, R.P.; Arch. Biochem. Biophys. 435, 243-252 (2005)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
4.1.3.1
H2O2
inhibits enzyme activity with increased concentrations, no activity above 1.3 mM
Ricinus communis
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.1.3.1
glyoxysome
-
Ricinus communis
9514
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.1.3.1
Ricinus communis
-
-
-
Oxidation Stability
EC Number
Oxidation Stability
Organism
4.1.3.1
H2O2 inactivates isocitrate lyase and degrades its product glyoxylate. Gel filtration, cross-linking and co-immunoprecipitation studies indicate association of isocitrate lyase with catalase, this would afford protection from H2O2.
Ricinus communis
Purification (Commentary)
EC Number
Commentary
Organism
4.1.3.1
-
Ricinus communis
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.3.1
isocitrate
-
663767
Ricinus communis
succinate + glyoxylate
-
-
-
?
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
4.1.3.1
H2O2
inhibits enzyme activity with increased concentrations, no activity above 1.3 mM
Ricinus communis
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.1.3.1
glyoxysome
-
Ricinus communis
9514
-
Oxidation Stability (protein specific)
EC Number
Oxidation Stability
Organism
4.1.3.1
H2O2 inactivates isocitrate lyase and degrades its product glyoxylate. Gel filtration, cross-linking and co-immunoprecipitation studies indicate association of isocitrate lyase with catalase, this would afford protection from H2O2.
Ricinus communis
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
4.1.3.1
-
Ricinus communis
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.3.1
isocitrate
-
663767
Ricinus communis
succinate + glyoxylate
-
-
-
?