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Literature summary extracted from

  • Valizadeh, M.; Schenk, G.; Nash, K.; Oddie, G.W.; Guddat, L.W.; Hume, D.A.; de Jersey, J.; Burke, T.R.; Hamilton, S.
    Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases (2004), Arch. Biochem. Biophys., 424, 154-162.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.2 expression in Spodopetra frugiperda Sf9 cells using the baculovirus infection system Mus musculus
3.1.3.2 expression in Spodopetra frugiperda Sf9 cells using the baculovirus infection system Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.2 4'-O-(2-fluoromalonyl)-L-tyrosine-containing peptides inhibitory potency, overview Homo sapiens
3.1.3.2 4'-O-(2-fluoromalonyl)-L-tyrosine-containing peptides inhibitory potency, overview Ipomoea batatas
3.1.3.2 4'-O-(2-fluoromalonyl)-L-tyrosine-containing peptides inhibitory potency, overview Mus musculus
3.1.3.2 4'-O-(2-fluoromalonyl)-L-tyrosine-containing peptides inhibitory potency, overview Phaseolus vulgaris
3.1.3.2 4'-O-(2-fluoromalonyl)-L-tyrosine-containing peptides inhibitory potency, overview Sus scrofa
3.1.3.2 4'-O-(2-malonyl)-L-tyrosine-containing peptides inhibitory potency, overview Homo sapiens
3.1.3.2 4'-O-(2-malonyl)-L-tyrosine-containing peptides inhibitory potency, overview Ipomoea batatas
3.1.3.2 4'-O-(2-malonyl)-L-tyrosine-containing peptides inhibitory potency, overview Mus musculus
3.1.3.2 4'-O-(2-malonyl)-L-tyrosine-containing peptides inhibitory potency, overview Phaseolus vulgaris
3.1.3.2 4'-O-(2-malonyl)-L-tyrosine-containing peptides inhibitory potency, overview Sus scrofa
3.1.3.2 additional information inhibitor-enzyme interaction Homo sapiens
3.1.3.2 additional information inhibitor-enzyme interaction Ipomoea batatas
3.1.3.2 additional information inhibitor-enzyme interaction Mus musculus
3.1.3.2 additional information inhibitor-enzyme interaction Phaseolus vulgaris
3.1.3.2 additional information inhibitor-enzyme interaction Sus scrofa
3.1.3.2 phospho-L-tyrosine peptide analogues inhibitory potency of several Fmoc-O,O-tert-butyl phospho-L-tyrosine analogue peptides, overview Homo sapiens
3.1.3.2 phospho-L-tyrosine peptide analogues inhibitory potency of several Fmoc-O,O-tert-butyl phospho-L-tyrosine analogue peptides, overview Ipomoea batatas
3.1.3.2 phospho-L-tyrosine peptide analogues inhibitory potency of several Fmoc-O,O-tert-butyl phospho-L-tyrosine analogue peptides, overview Mus musculus
3.1.3.2 phospho-L-tyrosine peptide analogues inhibitory potency of several Fmoc-O,O-tert-butyl phospho-L-tyrosine analogue peptides, overview Phaseolus vulgaris
3.1.3.2 phospho-L-tyrosine peptide analogues inhibitory potency of several Fmoc-O,O-tert-butyl phospho-L-tyrosine analogue peptides, overview Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.2 additional information
-
 additional information kinetics Phaseolus vulgaris
3.1.3.2 additional information
-
 additional information kinetics Mus musculus
3.1.3.2 additional information
-
 additional information kinetics Homo sapiens
3.1.3.2 additional information
-
 additional information kinetics Ipomoea batatas
3.1.3.2 additional information
-
 additional information kinetics Sus scrofa
3.1.3.2 0.006
-
 Fmoc-EEY(P)AA pH 2.5, 25°C Sus scrofa
3.1.3.2 0.008
-
 Fmoc-EY(P)A pH 2.5, 25°C Sus scrofa
3.1.3.2 0.048
-
 Fmoc-EY(P)A pH 4.9, 25°C Sus scrofa
3.1.3.2 0.075
-
 Fmoc-EEY(P)AA pH 4.9, 25°C Sus scrofa
3.1.3.2 0.12
-
 Fmoc-AAY(P)AA pH 4.9, 25°C Sus scrofa
3.1.3.2 0.14
-
 EEY(P)AA pH 2.5, 25°C Sus scrofa
3.1.3.2 0.31
-
 EEY(P)AA pH 4.9, 25°C Sus scrofa
3.1.3.2 0.95
-
 Fmoc-KKAY(P)AA pH 4.9, 25°C Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.2 Iron required Mus musculus
3.1.3.2 Iron required Homo sapiens
3.1.3.2 Iron required Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.2 Homo sapiens
-
-
-
3.1.3.2 Ipomoea batatas
-
 sweet potato
-
3.1.3.2 Mus musculus
-
-
-
3.1.3.2 Phaseolus vulgaris
-
 red kidney bean
-
3.1.3.2 Sus scrofa P09889
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.3.2 recombinant enzyme to over 95% purity Mus musculus
3.1.3.2 recombinant enzyme to over 95% purity Homo sapiens
3.1.3.2 to over 95% purity Phaseolus vulgaris
3.1.3.2 to over 95% purity Ipomoea batatas
3.1.3.2 to over 95% purity Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.2 allantoic fluid
-
 Sus scrofa
-
3.1.3.2 seed
-
 Phaseolus vulgaris
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.2 4-nitrophenyl phosphate + H2O
-
 Phaseolus vulgaris 4-nitrophenol + phosphate
-
 ?
3.1.3.2 4-nitrophenyl phosphate + H2O
-
 Mus musculus 4-nitrophenol + phosphate
-
 ?
3.1.3.2 4-nitrophenyl phosphate + H2O
-
 Homo sapiens 4-nitrophenol + phosphate
-
 ?
3.1.3.2 4-nitrophenyl phosphate + H2O
-
 Ipomoea batatas 4-nitrophenol + phosphate
-
 ?
3.1.3.2 4-nitrophenyl phosphate + H2O
-
 Sus scrofa 4-nitrophenol + phosphate
-
 ?
3.1.3.2 EEY(P)AA + H2O
-
 Sus scrofa EEYAA + phosphate
-
 ?
3.1.3.2 Fmoc-AAY(P)AA + H2O
-
 Sus scrofa Fmoc-AAYAA + phosphate
-
 ?
3.1.3.2 Fmoc-EEY(P)AA + H2O
-
 Sus scrofa Fmoc-EEYAA + phosphate
-
 ?
3.1.3.2 Fmoc-EY(P)A + H2O
-
 Sus scrofa Fmoc-EYA + phosphate
-
 ?
3.1.3.2 Fmoc-KKAY(P)AA + H2O
-
 Sus scrofa Fmoc-KKAYAA + phosphate
-
 ?
3.1.3.2 Fmoc-KKY(P)AA + H2O
-
 Sus scrofa Fmoc-KKYAA + phosphate
-
 ?
3.1.3.2 additional information substrate specificity Sus scrofa ?
-
 ?
3.1.3.2 phospho-L-tyrosine + H2O
-
 Phaseolus vulgaris L-tyrosine + phosphate
-
 ?
3.1.3.2 phospho-L-tyrosine + H2O
-
 Mus musculus L-tyrosine + phosphate
-
 ?
3.1.3.2 phospho-L-tyrosine + H2O
-
 Homo sapiens L-tyrosine + phosphate
-
 ?
3.1.3.2 phospho-L-tyrosine + H2O
-
 Ipomoea batatas L-tyrosine + phosphate
-
 ?
3.1.3.2 phospho-L-tyrosine + H2O
-
 Sus scrofa L-tyrosine + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.2 purple acid phosphatase
-
 Phaseolus vulgaris
3.1.3.2 purple acid phosphatase
-
 Mus musculus
3.1.3.2 purple acid phosphatase
-
 Homo sapiens
3.1.3.2 purple acid phosphatase
-
 Ipomoea batatas
3.1.3.2 purple acid phosphatase
-
 Sus scrofa

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.3.2 25
-
 Fmoc-EY(P)A pH 2.5, 25°C Sus scrofa
3.1.3.2 31
-
 Fmoc-EY(P)A pH 4.9, 25°C Sus scrofa
3.1.3.2 35
-
 Fmoc-EEY(P)AA pH 2.5, 25°C Sus scrofa
3.1.3.2 65
-
 EEY(P)AA pH 2.5, 25°C Sus scrofa
3.1.3.2 79
-
 EEY(P)AA pH 4.9, 25°C Sus scrofa
3.1.3.2 100
-
 Fmoc-AAY(P)AA pH 4.9, 25°C Sus scrofa
3.1.3.2 120
-
 Fmoc-EEY(P)AA pH 4.9, 25°C Sus scrofa
3.1.3.2 170
-
 Fmoc-KKAY(P)AA pH 4.9, 25°C Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.2 3 3.5 highest catalytic efficiency Phaseolus vulgaris
3.1.3.2 3 3.5 highest catalytic efficiency Sus scrofa

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.3.2 3 6 pH profile Sus scrofa