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Literature summary extracted from

  • Power, P.; Galleni, M.; Ayala, J.A.; Gutkind, G.
    Biochemical and molecular characterization of three new variants of AmpC beta-lactamases from Morganella morganii (2006), Antimicrob. Agents Chemother., 50, 962-967.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.2.6
-
Morganella morganii subsp. morganii
3.5.2.6 expressed in Escherichia coli Morganella morganii subsp. morganii
3.5.2.6 pMB19-2 plasmid, expression in Escherichia coli Morganella morganii subsp. morganii

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.2.6 aztreonam effective inhibitor; effective inhibitor; effective inhibitor Morganella morganii subsp. morganii
3.5.2.6 carbenicillin effective inhibitor; effective inhibitor; effective inhibitor Morganella morganii subsp. morganii
3.5.2.6 tazobactam effective inhibitor; effective inhibitor; effective inhibitor Morganella morganii subsp. morganii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.2.6 0.000003
-
Oxacillin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.000018
-
cefoxitin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.00002
-
cefotaxime 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.00002
-
cefotaxime in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 0.00006
-
ampicillin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 0.00008
-
ampicillin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.00008
-
ampicillin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 0.00009
-
cefotaxime in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 0.00013
-
ampicillin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.00013
-
ampicillin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 0.00017
-
piperacillin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.00025
-
benzylpenicillin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.0005
-
cefotaxime 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.0005
-
cefotaxime in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 0.0009
-
ceftazidime 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.001
-
Imipenem in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 0.002
-
Imipenem 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.002
-
Imipenem in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 0.004
-
Imipenem 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.004
-
Imipenem in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 0.025
-
nitrocefin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.046
-
cephalothin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.046
-
cephalothin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 0.06
-
ampicillin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.09
-
cefotaxime 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.095
-
cefepime 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.106
-
cephalothin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 0.148
-
cephalothin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.148
-
cephalothin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 1
-
Imipenem 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 106
-
cephalothin 30°C, pH 7.0 Morganella morganii subsp. morganii

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Morganella morganii subsp. morganii Q704Y9
-
-
3.5.2.6 Morganella morganii subsp. morganii Q704Z0
-
-
3.5.2.6 Morganella morganii subsp. morganii Q705J0
-
-
3.5.2.6 Morganella morganii subsp. morganii PP19 Q705J0
-
-
3.5.2.6 Morganella morganii subsp. morganii PP29 Q704Z0
-
-
3.5.2.6 Morganella morganii subsp. morganii PP37 Q704Y9
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.2.6
-
Morganella morganii subsp. morganii
3.5.2.6 Sephadex G-100 column chromatography, CM-Sepharose column chromatography Morganella morganii subsp. morganii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.6 ampicillin + H2O
-
Morganella morganii subsp. morganii (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
3.5.2.6 ampicillin + H2O
-
Morganella morganii subsp. morganii PP37 (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
3.5.2.6 ampicillin + H2O
-
Morganella morganii subsp. morganii PP19 (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
3.5.2.6 ampicillin + H2O
-
Morganella morganii subsp. morganii PP29 (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
3.5.2.6 benzylpenicillin + H2O
-
Morganella morganii subsp. morganii (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
3.5.2.6 benzylpenicillin + H2O
-
Morganella morganii subsp. morganii PP37 (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
3.5.2.6 benzylpenicillin + H2O
-
Morganella morganii subsp. morganii PP19 (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
3.5.2.6 benzylpenicillin + H2O
-
Morganella morganii subsp. morganii PP29 (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
3.5.2.6 cefepime + H2O
-
Morganella morganii subsp. morganii (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
3.5.2.6 cefotaxime + H2O
-
Morganella morganii subsp. morganii (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
3.5.2.6 cefotaxime + H2O
-
Morganella morganii subsp. morganii PP37 (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
3.5.2.6 cefotaxime + H2O
-
Morganella morganii subsp. morganii PP19 (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
3.5.2.6 cefotaxime + H2O
-
Morganella morganii subsp. morganii PP29 (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
3.5.2.6 cefoxitin + H2O
-
Morganella morganii subsp. morganii (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
3.5.2.6 cefoxitin + H2O
-
Morganella morganii subsp. morganii PP37 (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
3.5.2.6 cefoxitin + H2O
-
Morganella morganii subsp. morganii PP19 (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
3.5.2.6 cefoxitin + H2O
-
Morganella morganii subsp. morganii PP29 (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
3.5.2.6 ceftazidime + H2O
-
Morganella morganii subsp. morganii (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
3.5.2.6 cephalothin + H2O
-
Morganella morganii subsp. morganii (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
3.5.2.6 cephalothin + H2O
-
Morganella morganii subsp. morganii PP37 (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
3.5.2.6 cephalothin + H2O
-
Morganella morganii subsp. morganii PP19 (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
3.5.2.6 cephalothin + H2O
-
Morganella morganii subsp. morganii PP29 (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
3.5.2.6 imipenem + H2O
-
Morganella morganii subsp. morganii (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
?
3.5.2.6 nitrocefin + H2O
-
Morganella morganii subsp. morganii (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
3.5.2.6 oxacillin + H2O
-
Morganella morganii subsp. morganii (2R,4S)-2-{(R)-carboxy[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
3.5.2.6 piperacillin + H2O
-
Morganella morganii subsp. morganii (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?

Synonyms

EC Number Synonyms Comment Organism
3.5.2.6 AmpC beta-lactamase
-
Morganella morganii subsp. morganii
3.5.2.6 AmpC beta-lactamases M19
-
Morganella morganii subsp. morganii
3.5.2.6 AmpC beta-lactamases M29
-
Morganella morganii subsp. morganii
3.5.2.6 AmpC beta-lactamases M37
-
Morganella morganii subsp. morganii
3.5.2.6 AmpC M19
-
Morganella morganii subsp. morganii
3.5.2.6 AmpC M29
-
Morganella morganii subsp. morganii
3.5.2.6 AmpC M37
-
Morganella morganii subsp. morganii
3.5.2.6 beta-lactamase, class C
-
Morganella morganii subsp. morganii
3.5.2.6 M19
-
Morganella morganii subsp. morganii
3.5.2.6 M29
-
Morganella morganii subsp. morganii
3.5.2.6 M37
-
Morganella morganii subsp. morganii

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.5.2.6 0.0074
-
benzylpenicillin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.008
-
cefepime 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.022
-
Oxacillin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.032
-
cefotaxime 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.032
-
cefotaxime in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 0.038
-
cefoxitin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.04
-
ceftazidime 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.06
-
ampicillin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.06
-
ampicillin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 0.065
-
ampicillin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.07
-
Imipenem 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.07
-
Imipenem in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 0.07
-
cefotaxime in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 0.09
-
cefotaxime in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 0.11
-
Imipenem 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 0.11
-
Imipenem in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 1.5
-
piperacillin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 6
-
cephalothin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 6
-
cephalothin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 14
-
cephalothin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 14
-
cephalothin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii
3.5.2.6 93
-
nitrocefin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 140
-
cephalothin 30°C, pH 7.0 Morganella morganii subsp. morganii
3.5.2.6 140
-
cephalothin in 20 mM phosphate buffer, (pH 7.0) at 30°C Morganella morganii subsp. morganii

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.5.2.6 Morganella morganii subsp. morganii isoelectric focusing
-
6.6
3.5.2.6 Morganella morganii subsp. morganii isoelectric focusing, pH-range 3-10
-
6.6
3.5.2.6 Morganella morganii subsp. morganii isoelectric focusing
-
7.4
3.5.2.6 Morganella morganii subsp. morganii isoelectric focusing, pH-range 3-10
-
7.4
3.5.2.6 Morganella morganii subsp. morganii isoelectric focusing
-
7.8
3.5.2.6 Morganella morganii subsp. morganii isoelectric focusing, pH-range 3-10
-
7.8