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Literature summary extracted from

  • Bauvois, C.; Ibuka, A.S.; Celso, A.; Alba, J.; Ishii, Y.; Frere, J.M.; Galleni, M.
    Kinetic properties of four plasmid-mediated AmpC beta-lactamases (2005), Antimicrob. Agents Chemother., 49, 4240-4246.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.2.6 3-aminophenyl boronic acid plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.2.6 0.0000006
-
 Oxacillin 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 0.0000011
-
 cefoxitin 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 0.0000012
-
 cefuroxime 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 0.000004
-
 aztreonam 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 0.000005
-
 cefuroxime 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.00001
-
 aztreonam 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.000015
-
 cefotaxime 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.000019
-
 cefuroxime 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 0.00002
-
 Oxacillin 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.00005
-
 Imipenem 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.000055
-
 cefoxitin 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.00007
-
 cefotaxime 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 0.00009
-
 Oxacillin 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 0.0001
-
 Oxacillin 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 0.00015
-
 Imipenem 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 0.00016
-
 ampicillin 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 0.00016
-
 ampicillin 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 0.00037
-
 Imipenem 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 0.0004
-
 benzylpenicillin 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 0.0004
-
 benzylpenicillin 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 0.0005
-
 cefoxitin 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 0.0006
-
 cefuroxime 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 0.00075
-
 cefoxitin 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 0.001
-
 benzylpenicillin 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.0017
-
 ampicillin 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 0.0021
-
 benzylpenicillin 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 0.0021
-
 cephalothin 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 0.0021
-
 cephalothin 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 0.0022
-
 ampicillin 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.004
-
 cefotaxime 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 0.008
-
 nitrocefin 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 0.008
-
 nitrocefin 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 0.014
-
 cephalexin 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.016
-
 cephalexin 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 0.016
-
 cephalexin 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 0.022
-
 nitrocefin 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 0.03
-
 cephalothin 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.038
-
 cephalothin 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 0.042
-
 cephalexin 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 0.054
-
 cefazolin 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.093
-
 cephaloridine 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 0.093
-
 cephaloridine 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 0.11
-
 cephaloridine 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.23
-
 nitrocefin 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.43
-
 cefazolin 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Escherichia coli
-
 plasmid-encoded, pBC1e, beta-lactamase ACT-1
-
3.5.2.6 Escherichia coli
-
 plasmid-encoded, pBC2e, beta-lactamase MIR-1
-
3.5.2.6 Escherichia coli
-
 plasmid-encoded, pBC3e, beta-lactamase CMY-1
-
3.5.2.6 Escherichia coli
-
 plasmid-encoded, pBC4e, beta-lactamase CMY-2
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.2.6
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.6 ampicillin + H2O plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 ampicillin + H2O plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 ampicillin + H2O plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 ampicillin + H2O plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 aztreonam + H2O
-
 Escherichia coli [(1S,2S)-1-[[(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-1-carboxypropan-2-yl]sulfamate
-
 ?
3.5.2.6 benzylpenicillin + H2O plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 benzylpenicillin + H2O plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 benzylpenicillin + H2O plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 benzylpenicillin + H2O plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 cefazolin + H2O plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli (2R)-2-[(R)-carboxy[(1H-tetrazol-1-ylacetyl)amino]methyl]-5-[[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefazolin + H2O plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli (2R)-2-[(R)-carboxy[(1H-tetrazol-1-ylacetyl)amino]methyl]-5-[[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefazolin + H2O plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli (2R)-2-[(R)-carboxy[(1H-tetrazol-1-ylacetyl)amino]methyl]-5-[[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefazolin + H2O plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli (2R)-2-[(R)-carboxy[(1H-tetrazol-1-ylacetyl)amino]methyl]-5-[[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefotaxime + H2O plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefotaxime + H2O plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefotaxime + H2O plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefotaxime + H2O plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefoxitin + H2O plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefoxitin + H2O plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefoxitin + H2O plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefoxitin + H2O plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefuroxime + H2O plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefuroxime + H2O plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefuroxime + H2O plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefuroxime + H2O plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cephalexin + H2O plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli (2R)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cephalexin + H2O plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli (2R)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cephalexin + H2O plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli (2R)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cephalexin + H2O plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli (2R)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cephaloridine + H2O plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cephaloridine + H2O plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cephaloridine + H2O plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cephaloridine + H2O plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cephalothin + H2O plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cephalothin + H2O plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cephalothin + H2O plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cephalothin + H2O plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 imipenem + H2O plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 imipenem + H2O plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 imipenem + H2O plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 imipenem + H2O plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 nitrocefin + H2O plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 nitrocefin + H2O plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 nitrocefin + H2O plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 nitrocefin + H2O plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 oxacillin + H2O plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli (2R,4S)-2-{(R)-carboxy[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 oxacillin + H2O plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli (2R,4S)-2-{(R)-carboxy[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 oxacillin + H2O plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli (2R,4S)-2-{(R)-carboxy[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 oxacillin + H2O plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli (2R,4S)-2-{(R)-carboxy[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.2.6 beta-lactamase ACT-1
-
 Escherichia coli
3.5.2.6 beta-lactamase CMY-1
-
 Escherichia coli
3.5.2.6 beta-lactamase CMY-2
-
 Escherichia coli
3.5.2.6 beta-lactamase MIR-1
-
 Escherichia coli

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.5.2.6 0.002
-
 Imipenem 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.004
-
 cefotaxime 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 0.009
-
 Oxacillin 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.01
-
 cefotaxime 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.011
-
 Imipenem 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 0.012
-
 Imipenem 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 0.015
-
 Oxacillin 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 0.017
-
 cefuroxime 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 0.02
-
 cefuroxime 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.033
-
 Imipenem 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 0.044
-
 Oxacillin 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 0.05
-
 cefotaxime 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 0.05
-
 cefoxitin 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.12
-
 cefuroxime 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 0.18
-
 Oxacillin 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 0.23
-
 cefoxitin 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 0.37
-
 cefoxitin 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 0.55
-
 ampicillin 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 0.55
-
 ampicillin 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 0.55
-
 ampicillin 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 0.64
-
 cefoxitin 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 1
-
 ampicillin 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 2.7
-
 cefotaxime 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 3.4
-
 cefuroxime 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 13
-
 benzylpenicillin 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 14
-
 benzylpenicillin 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 14
-
 benzylpenicillin 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 55
-
 benzylpenicillin 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 55
-
 cephalexin 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 55
-
 cephalexin 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 85
-
 cephalexin 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 115
-
 cephalexin 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 155
-
 cephaloridine 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 160
-
 cephalothin 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 160
-
 cephalothin 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 215
-
 cephaloridine 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 215
-
 cephaloridine 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 325
-
 cefazolin 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 400
-
 nitrocefin 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 460
-
 cephalothin 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 480
-
 cephalothin 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli
3.5.2.6 560
-
 cefazolin 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli
3.5.2.6 765
-
 nitrocefin 30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1 Escherichia coli
3.5.2.6 765
-
 nitrocefin 30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2 Escherichia coli
3.5.2.6 2220
-
 nitrocefin 30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1 Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.2.6 0.086
-
 3-aminophenyl boronic acid 30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1 Escherichia coli