Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lau, S.K.; Ho, P.L.; Li, M.W.; Tsoi, H.W.; Yung, R.W.; Woo, P.C.; Yuen, K.Y.
    Cloning and characterization of a chromosomal class C beta-lactamase and its regulatory gene in Laribacter hongkongensis (2005), Antimicrob. Agents Chemother., 49, 1957-1964.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.2.6
-
 Laribacter hongkongensis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.2.6 clavulanate IC50: 0.138 mM Laribacter hongkongensis
3.5.2.6 Cloxacillin IC50: 0.0035 mM Laribacter hongkongensis
3.5.2.6 Sulbactam IC50: 0.057 mM Laribacter hongkongensis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.2.6 0.056
-
 cephalothin
-
 Laribacter hongkongensis
3.5.2.6 0.088
-
 cephaloridine
-
 Laribacter hongkongensis
3.5.2.6 0.356
-
 benzylpenicillin
-
 Laribacter hongkongensis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.2.6 additional information Laribacter hongkongensis expression of the ampC gene of HLHK5 is regulated by its ampR gene, which acts as a repressor ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Laribacter hongkongensis Q6GVZ4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.6 benzylpenicillin + H2O 2.8% of the activity with cephaloridine Laribacter hongkongensis (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 cefepime + H2O 1.05% of the activity with cephaloridine Laribacter hongkongensis (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cephaloridine + H2O
-
 Laribacter hongkongensis (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cephalothin + H2O 101% of the activity with cephaloridine Laribacter hongkongensis (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 additional information expression of the ampC gene of HLHK5 is regulated by its ampR gene, which acts as a repressor Laribacter hongkongensis ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.2.6 AmpC beta-lactamase
-
 Laribacter hongkongensis
3.5.2.6 LHK-5
-
 Laribacter hongkongensis

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.5.2.6 Laribacter hongkongensis isolelectric focusing, pH-range 3.5-9.5
-
 8.1

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.2.6 0.0035
-
 IC50: 0.0035 mM Laribacter hongkongensis Cloxacillin
3.5.2.6 0.057
-
 IC50: 0.057 mM Laribacter hongkongensis Sulbactam
3.5.2.6 0.138
-
 IC50: 0.138 mM Laribacter hongkongensis clavulanate