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Literature summary extracted from

  • Castanheira, M.; Toleman, M.A.; Jones, R.N.; Schmidt, F.J.; Walsh, T.R.
    Molecular characterization of a beta-lactamase gene, blaGIM-1, encoding a new subclass of metallo-beta-lactamase (2004), Antimicrob. Agents Chemother., 48, 4654-4661.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.2.6 0.004
-
 cefotaxime 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 0.007
-
 cefuroxime 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 0.012
-
 nitrocefin 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 0.02
-
 ampicillin 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 0.022
-
 cephalothin 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 0.025
-
 meropenem 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 0.031
-
 ceftazidime 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 0.046
-
 penicillin 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 0.057
-
 ticarcillin 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 0.069
-
 piperacillin 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 0.17
-
 carbenicillin 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 0.206
-
 cefoxitin 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 0.287
-
 Imipenem 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 0.431
-
 cefepime 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 1.035
-
 moxalactam 25°C, pH 7.0 Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Pseudomonas aeruginosa Q704U4
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.2.6
-
 Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.6 a penicillin + H2O
-
 Pseudomonas aeruginosa a penicilloic acid
-
 ?
3.5.2.6 ampicillin + H2O
-
 Pseudomonas aeruginosa (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 carbenicillin + H2O
-
 Pseudomonas aeruginosa (2R,4S)-2-{(R)-carboxy[2-carboxy(phenyl)acetamido]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 cefepime + H2O
-
 Pseudomonas aeruginosa (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cefotaxime + H2O
-
 Pseudomonas aeruginosa (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cefoxitin + H2O
-
 Pseudomonas aeruginosa (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 ceftazidime + H2O
-
 Pseudomonas aeruginosa (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cefuroxime + H2O
-
 Pseudomonas aeruginosa (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cephalothin + H2O
-
 Pseudomonas aeruginosa (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 imipenem + H2O
-
 Pseudomonas aeruginosa (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 meropenem + H2O
-
 Pseudomonas aeruginosa (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 moxalactam + H2O
-
 Pseudomonas aeruginosa (2R)-2-{(R)-carboxy[2-carboxy(4-hydroxyphenyl)acetamido]methoxymethyl}-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-oxazine-4-carboxylic acid
-
 ?
3.5.2.6 nitrocefin + H2O
-
 Pseudomonas aeruginosa (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 penicillin + H2O
-
 Pseudomonas aeruginosa ?
-
 ?
3.5.2.6 piperacillin + H2O
-
 Pseudomonas aeruginosa (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 ticarcillin + H2O
-
 Pseudomonas aeruginosa (2R,4S)-2-[(R)-carboxy[[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.2.6 GIM-1
-
 Pseudomonas aeruginosa

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.5.2.6 1.1
-
 cefotaxime 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 2.3
-
 ticarcillin 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 2.7
-
 meropenem 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 3.3
-
 ampicillin 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 4.1
-
 carbenicillin 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 5.8
-
 nitrocefin 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 5.9
-
 cefuroxime 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 6.6
-
 penicillin 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 6.9
-
 piperacillin 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 8.3
-
 cefoxitin 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 14
-
 moxalactam 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 16
-
 cephalothin 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 17
-
 cefepime 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 18
-
 ceftazidime 25°C, pH 7.0 Pseudomonas aeruginosa
3.5.2.6 27
-
 Imipenem 25°C, pH 7.0 Pseudomonas aeruginosa

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.5.2.6 Pseudomonas aeruginosa isoelectric focusing, pH-range 3-10
-
 5.4