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Literature summary extracted from

  • Heritier, C.; Poirel, L.; Nordmann, P.
    Genetic and biochemical characterization of a chromosome-encoded carbapenem-hydrolyzing ambler class D beta-lactamase from Shewanella algae (2004), Antimicrob. Agents Chemother., 48, 1670-1675.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.2.6 expression in Escherichia coli Shewanella algae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.2.6 0.02
-
 Imipenem 30°C, pH 7.0 Shewanella algae
3.5.2.6 0.02
-
 ticarcillin 30°C, pH 7.0 Shewanella algae
3.5.2.6 0.025
-
 benzylpenicillin 30°C, pH 7.0 Shewanella algae
3.5.2.6 0.07
-
 cephalothin 30°C, pH 7.0 Shewanella algae
3.5.2.6 0.11
-
 piperacillin 30°C, pH 7.0 Shewanella algae
3.5.2.6 0.19
-
 Cloxacillin 30°C, pH 7.0 Shewanella algae
3.5.2.6 0.39
-
 Oxacillin 30°C, pH 7.0 Shewanella algae
3.5.2.6 0.5
-
 ampicillin 30°C, pH 7.0 Shewanella algae
3.5.2.6 0.5
-
 meropenem 30°C, pH 7.0 Shewanella algae
3.5.2.6 0.67
-
 cefpirome 30°C, pH 7.0 Shewanella algae
3.5.2.6 0.75
-
 cephaloridine 30°C, pH 7.0 Shewanella algae
3.5.2.6 4.7
-
 ceftazidime 30°C, pH 7.0 Shewanella algae

Organism

EC Number Organism UniProt Comment Textmining
3.5.2.6 Shewanella algae Q6VCW0 clinical isolate KB-1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.2.6 ampicillin + H2O
-
 Shewanella algae (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 benzylpenicillin + H2O
-
 Shewanella algae (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 cefpirome + H2O
-
 Shewanella algae (2S)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}(carboxy)methyl]-5-[(6,7-dihydro-5H-cyclopenta[b]pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 ceftazidime + H2O
-
 Shewanella algae (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cephaloridine + H2O
-
 Shewanella algae (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
3.5.2.6 cephalothin + H2O
-
 Shewanella algae (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
3.5.2.6 cloxacillin + H2O
-
 Shewanella algae (2R,4S)-2-[(R)-carboxy{[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 imipenem + H2O
-
 Shewanella algae (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 meropenem + H2O
-
 Shewanella algae (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
3.5.2.6 oxacillin + H2O
-
 Shewanella algae (2R,4S)-2-{(R)-carboxy[(5-methyl-3-phenyl-1,2-oxazole-4-carbonyl)amino]methyl}-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 piperacillin + H2O
-
 Shewanella algae (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
3.5.2.6 ticarcillin + H2O
-
 Shewanella algae (2R,4S)-2-[(R)-carboxy[[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.2.6 carbapenem-hydrolyzing ambler class D beta-lactamase
-
 Shewanella algae
3.5.2.6 OXA-55
-
 Shewanella algae

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.5.2.6 0.05
-
 meropenem 30°C, pH 7.0 Shewanella algae
3.5.2.6 0.1
-
 Imipenem 30°C, pH 7.0 Shewanella algae
3.5.2.6 0.1
-
 cefpirome 30°C, pH 7.0 Shewanella algae
3.5.2.6 0.5
-
 Cloxacillin 30°C, pH 7.0 Shewanella algae
3.5.2.6 0.6
-
 cephalothin 30°C, pH 7.0 Shewanella algae
3.5.2.6 1
-
 ticarcillin 30°C, pH 7.0 Shewanella algae
3.5.2.6 2
-
 ceftazidime 30°C, pH 7.0 Shewanella algae
3.5.2.6 3
-
 piperacillin 30°C, pH 7.0 Shewanella algae
3.5.2.6 4
-
 benzylpenicillin 30°C, pH 7.0 Shewanella algae
3.5.2.6 5
-
 Oxacillin 30°C, pH 7.0 Shewanella algae
3.5.2.6 8
-
 ampicillin 30°C, pH 7.0 Shewanella algae
3.5.2.6 10
-
 cephaloridine 30°C, pH 7.0 Shewanella algae