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Literature summary extracted from

  • Burns, F.R.; Paterson, C.A.; Gray, R.D.; Wells, J.T.
    Inhibition of Pseudomonas aeruginosa elastase and Pseudomonas keratitis using a thiol-based peptide (1990), Antimicrob. Agents Chemother., 34, 2065-2069.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.24.26 medicine the inhibitor may have a therapeutic application by delaying the progression of corneal destruction in Pseudomonas keratitis Pseudomonas aeruginosa

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.26 HSCH2(DL)CH[CH2CH(CH3)2]CO-Phe-Ala-NH2 2 isomeric forms Pseudomonas aeruginosa
3.4.24.26 additional information no inhibition by gentamicin Pseudomonas aeruginosa

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.26 Pseudomonas aeruginosa P14756 strain PA-28
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.26
-
 Pseudomonas aeruginosa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.26 azocasein + H2O
-
 Pseudomonas aeruginosa ?
-
 ?
3.4.24.26 furylacryloyl-glycyl-L-leucyl-L-alanine + H2O 25°C, pH 7.5 Pseudomonas aeruginosa furylacryloyl-glycine + L-leucyl-L-alanine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.26 Pseudomonas aeruginosa elastase
-
 Pseudomonas aeruginosa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.24.26 0.0003
-
 slowly eluting isomer of HSCH2(DL)CH[CH2CH(CH3)2]CO-Phe-Ala-NH2
-
 Pseudomonas aeruginosa
3.4.24.26 0.0004
-
 rapidly eluting isomer of HSCH2(DL)CH[CH2CH(CH3)2]CO-Phe-Ala-NH2
-
 Pseudomonas aeruginosa