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Literature summary extracted from

  • Zhou, L.; Tan, A.; Iasvovskaia, S.; Li, J.; Lin, A.; Hershenson, M.B.
    Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells (2003), Am. J. Respir. Cell Mol. Biol., 28, 762-769.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.25 additional information TNF-alpha induces MEKK1 and Ras activation Homo sapiens
2.7.11.25 Ras required for maximal activity in ERK and JNK phosphorylation/activation and for activation of AP-1 pathway Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.25 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.25 ATP + ERK Homo sapiens i.e. extracellular signal-regulated kinase ADP + phosphorylated ERK
-
 ?
2.7.11.25 ATP + JNK Homo sapiens i.e. Jun amino terminal kinase ADP + phosphorylated JNK
-
 ?
2.7.11.25 additional information Homo sapiens regulation, overview, Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells, the enzyme is involved in activation of the signaling cascades via activator protein AP-1 and NF-kappaB ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.25 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.25 16HBE14o cell bronchial epithelial cell line Homo sapiens
-
2.7.11.25 bronchus
-
 Homo sapiens
-
2.7.11.25 epithelial cell bronchial Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.25 ATP + ERK i.e. extracellular signal-regulated kinase Homo sapiens ADP + phosphorylated ERK
-
 ?
2.7.11.25 ATP + JNK i.e. Jun amino terminal kinase Homo sapiens ADP + phosphorylated JNK
-
 ?
2.7.11.25 additional information regulation, overview, Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells, the enzyme is involved in activation of the signaling cascades via activator protein AP-1 and NF-kappaB Homo sapiens ?
-
 ?
2.7.11.25 additional information no phosphorylation/activation of IkappaB kinase Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.25 extracellular signal-regulated kinase kinase kinase-1
-
 Homo sapiens
2.7.11.25 MAP kinase kinase kinase 1
-
 Homo sapiens
2.7.11.25 MEKK1
-
 Homo sapiens
2.7.11.25 mitogen-activated protein kinase kinase kinase-1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.25 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.25 7.5
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.25 ATP
-
 Homo sapiens