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Literature summary extracted from

  • Yamamoto, N.
    Pathogenic significance of alpha-N-acetylgalactosaminidase activity found in the envelope glycoprotein gp160 of human immunodeficiency virus Type 1 (2006), AIDS Res. Hum. Retroviruses, 22, 262-271.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.2.1.49 additional information the enzyme is inducible in patients peripheral blood mononuclear cells by HIV-1 provirus-inducing agent, overview Homo sapiens
3.2.1.49 Trypsin the enzyme needs to be proteolytically activated, activation of the enzyme by trypsin Human immunodeficiency virus 1

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.1.49 1.27
-
 serum vitamin D3-binding protein pH 6.1, 37°C Homo sapiens
3.2.1.49 1.27
-
 p-nitrophenyl N-acetyl-alpha-D-galactosaminide enzyme from HIV patient serum, at pH 6.1 Homo sapiens
3.2.1.49 4.83
-
 serum vitamin D3-binding protein pH 4.3, 37°C Human immunodeficiency virus 1
3.2.1.49 4.83
-
 p-nitrophenyl N-acetyl-alpha-D-galactosaminide constitutive lung enzyme, at pH 4.3 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.49 membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.49 additional information Human immunodeficiency virus 1 the enzyme plays a dual role in regulating both infectivity and immunosuppression ?
-
 ?
3.2.1.49 serum vitamin D3-binding protein + H2O Human immunodeficiency virus 1 i.e. Gc protein, the human substrate is the precursor of the principal macrophage activating factor, MAF, the deglycosylated prrecursor cannot be converted, which leads to immunosuppression ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.49 Homo sapiens
-
-
-
3.2.1.49 Human immunodeficiency virus 1
-
 i.e. HIV-1, constitutive enzyme
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.49 B-lymphocyte inducible enzyme Homo sapiens
-
3.2.1.49 lung
-
 Homo sapiens
-
3.2.1.49 mononuclear cell peripheral blood, inducible enzyme Homo sapiens
-
3.2.1.49 serum
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.2.1.49 additional information
-
-
 Homo sapiens
3.2.1.49 additional information
-
-
 Human immunodeficiency virus 1

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.49 additional information the enzyme plays a dual role in regulating both infectivity and immunosuppression Human immunodeficiency virus 1 ?
-
 ?
3.2.1.49 additional information the HIV-1 viral envelope glycoprotein gp160 shows alpha-N-galactosaminidase activity Human immunodeficiency virus 1 ?
-
 ?
3.2.1.49 p-nitrophenyl N-acetyl-alpha-D-galactosaminide + H2O
-
 Homo sapiens p-nitrophenol + N-acetyl-D-galactosamine
-
 ?
3.2.1.49 serum vitamin D3-binding protein + H2O i.e. Gc protein, the human substrate is the precursor of the principal macrophage activating factor, MAF, the deglycosylated prrecursor cannot be converted, which leads to immunosuppression Human immunodeficiency virus 1 ?
-
 ?
3.2.1.49 serum vitamin D3-binding protein + H2O i.e. Gc protein, human substrate, deglycosylation of the substrate Homo sapiens ?
-
 ?
3.2.1.49 serum vitamin D3-binding protein + H2O i.e. Gc protein, human substrate, deglycosylation of the substrate Human immunodeficiency virus 1 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.49 envelope glycoprotein gp160
-
 Homo sapiens
3.2.1.49 envelope glycoprotein gp160
-
 Human immunodeficiency virus 1
3.2.1.49 NaGalase
-
 Homo sapiens
3.2.1.49 NaGalase
-
 Human immunodeficiency virus 1

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.1.49 37
-
 assay at Homo sapiens
3.2.1.49 37
-
 assay at Human immunodeficiency virus 1

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.49 4.3
-
-
 Human immunodeficiency virus 1
3.2.1.49 4.3
-
 constitutive lung enzyme Homo sapiens
3.2.1.49 6.1
-
-
 Homo sapiens
3.2.1.49 6.1
-
 enzyme from HIV patient serum Homo sapiens