Any feedback?
Literature summary extracted from
- Aminopeptidase A (2004), Handbook of Proteolytic Enyzmes (2nd Edition), 1, 299-303.
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.7 | 1,10-phenanthroline | - |
Cavia porcellus |  |
| 3.4.11.7 | Cd2+ | complete inhibition at 1 mM | Cavia porcellus | |
| 3.4.11.7 | Cu2+ | complete inhibition at 1 mM | Cavia porcellus | |
| 3.4.11.7 | EC33 | specific inhibition | Cavia porcellus | |
| 3.4.11.7 | EDTA | - |
Cavia porcellus | |
| 3.4.11.7 | EGTA | - |
Cavia porcellus | |
| 3.4.11.7 | Hg2+ | complete inhibition at 1 mM | Cavia porcellus | |
| 3.4.11.7 | Ni2+ | complete inhibition at 1 mM | Cavia porcellus | |
| 3.4.11.7 | RB150 | selective and specific prodrug of the enzyme inhibitor EC33, inhibits the enzyme given i.v. to rats | Cavia porcellus | |
| 3.4.11.7 | Zn2+ | complete inhibition at 1 mM | Cavia porcellus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.11.7 | cytoplasm | the enzyme has cytosolic and transmembrane regions | Cavia porcellus | 5737 | - |
| 3.4.11.7 | membrane | the enzyme has cytosolic and transmembrane regions | Cavia porcellus | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.11.7 | Ca2+ | activates | Cavia porcellus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.7 | 45000 | 400000 | dependent on the tissue source and purification method | Cavia porcellus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.11.7 | Cavia porcellus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.11.7 | enterocyte | intestinal, brush border | Cavia porcellus | - |
| 3.4.11.7 | kidney | brush border | Cavia porcellus | - |
| 3.4.11.7 | additional information | broad tissue distribution | Cavia porcellus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.11.7 | additional information | the enzyme catalyzes the hydrolysis of N-(alpha-L-glutamyl)- moieties more efficiently than the hydrolysis of alpha-L-aspartyl derivatives | Cavia porcellus | ? | - |
? | |
| 3.4.11.7 | N-(alpha-L-glutamyl)-4-nitroanilide + H2O | - |
Cavia porcellus | L-glutamic acid + 4-nitroaniline | - |
? | |
| 3.4.11.7 | N-(alpha-L-glutamyl)-beta-naphthylamide + H2O | - |
Cavia porcellus | L-glutamic acid + beta-naphthylamine | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.11.7 | acidic alpha-aminopeptidase | - |
Cavia porcellus |
| 3.4.11.7 | aminopeptidase A | - |
Cavia porcellus |
| 3.4.11.7 | angiotensinase A | - |
Cavia porcellus |
| 3.4.11.7 | APA | - |
Cavia porcellus |
| 3.4.11.7 | aspartate aminopeptidase | - |
Cavia porcellus |
| 3.4.11.7 | Ca2+-activated glutamate aminopeptidase | - |
Cavia porcellus |
| 3.4.11.7 | EAP | - |
Cavia porcellus |
| 3.4.11.7 | glutamyl aminopeptidase | - |
Cavia porcellus |
| 3.4.11.7 | membrane aminopeptidase II | - |
Cavia porcellus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.7 | 37 | - |
assay at | Cavia porcellus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.11.7 | 7.2 | - |
approximately | Cavia porcellus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
