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Literature summary extracted from

  • Zurek, J.; Bowman, A.L.; Sokalski, W.A.; Mulholland, A.J.
    MM and QM/MM modeling of threonyl-tRNA synthetase: model testing and simulations (2004), Struct. Chem., 15, 405-414.
No PubMed abstract available

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.1.1.3 crystal structure, PDB code 1EVL, at 1.55 A resolution used for reaction mechanism analysis and molecular modeling Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.1.1.3 Mg2+ binding and structure modeling, ligand coordination Escherichia coli
6.1.1.3 Zn2+ binding and structure modeling, ligand coordination Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.3 ATP + L-threonine + tRNAThr Escherichia coli
-
 AMP + diphosphate + L-threonyl-tRNAThr
-
 r

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.3 Escherichia coli P0A8M3
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
6.1.1.3 ATP + L-threonine + tRNAThr = AMP + diphosphate + L-threonyl-tRNAThr reaction mechanism analysis by QM/MM and MM modeling of full length and truncated enzyme, molecular mechanism simulation Escherichia coli
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.3 ATP + L-threonine + tRNAThr
-
 Escherichia coli AMP + diphosphate + L-threonyl-tRNAThr
-
 r
6.1.1.3 ATP + L-threonine + tRNAThr via AMP-L-threonine-enzyme intermediate in a two-step process Escherichia coli AMP + diphosphate + L-threonyl-tRNAThr
-
 r

Synonyms

EC Number Synonyms Comment Organism
6.1.1.3 Threonyl-tRNA synthetase
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.3 AMP
-
 Escherichia coli
6.1.1.3 ATP
-
 Escherichia coli