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Literature summary extracted from

  • Kim, C.; Xuong, N.H.; Taylor, S.S.
    Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA (2005), Science, 307, 690-696.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 cAMP dependent on, structural basis of activation mechanism, binding induces conformational changes in the regulatory subunit RIalpha Mus musculus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.11.11 complex between the catalytic subunit and a deletion mutant regulatory subunit RIalpha comprising residues 91-244, structure determination and analysis Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.11 IP20 peptide RRNAI, derived from the inhibitory sequence of RIalpha comprising residues 94-98, inhibition mechanism Mus musculus
2.7.11.11 additional information molecular mechanism of enzyme inhibition by binding of catalytic and regulatory subunits via extended surface of subunit C, overview Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.11 Mg2+
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Mus musculus
-
-
-

Subunits

EC Number Subunits Comment Organism
2.7.11.11 More structure of subunit C, subunit R, the cAMP binding site, and the activation loop, interaction sites, overview Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKA
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Mus musculus