Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Rodriguez-Gonzalez, A.; Ramirez de Molina, A.; Benitez-Rajal, J.; Lacal, J.C.
    Phospholipase D and choline kinase: their role in cancer development and their potential as drug targets (2003), Prog. Cell Cycle Res., 5, 191-201.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.1.32 medicine potential target for anti-tumor drugs, potential use of the enzyme level as tumor marker Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.32 5,5'-dithiobis(2-nitrobenzoic acid)
-
 Homo sapiens
2.7.1.32 5,5'-dithiobis(2-nitrobenzoic acid)
-
 Mus musculus
2.7.1.32 adenosine competitive with MgATP2- Homo sapiens
2.7.1.32 adenosine competitive with MgATP2- Mus musculus
2.7.1.32 Choline analogues several compounds tested and found to be inhibitory Homo sapiens
2.7.1.32 Choline analogues several compounds tested and found to be inhibitory Mus musculus
2.7.1.32 hemicholinium HC-3 Homo sapiens
2.7.1.32 hemicholinium HC-3 Mus musculus
2.7.1.32 KF
-
 Homo sapiens
2.7.1.32 KF
-
 Mus musculus
2.7.1.32 N-ethylmaleimide
-
 Homo sapiens
2.7.1.32 N-ethylmaleimide
-
 Mus musculus
2.7.1.32 stearoyl-CoA
-
 Homo sapiens
2.7.1.32 stearoyl-CoA
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.32 cytosol
-
 Mus musculus 5829
-
2.7.1.32 cytosol
-
 Homo sapiens 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.32 Mg2+ required Mus musculus
2.7.1.32 Mg2+ required Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.32 42000
-
 subtype beta, mainly dimers and tetramers, x * 42000 Mus musculus
2.7.1.32 50000
-
 mainly dimers and tetramers, x * 50000 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.32 ATP + choline Mus musculus initial step of the Kennedy pathway, that yields phosphatidylcholine as final product, involved in mitogenic signaling transduction ADP + O-phosphocholine
-
 ?
2.7.1.32 ATP + choline Homo sapiens initial step of the Kennedy pathway, that yields phosphatidylcholine as final product, involved in mitogenic signaling transduction, the product O-phosphocholine serves as second messenger and is essential for cell growth, enzyme plays a role in tumor generation ADP + O-phosphocholine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.32 Homo sapiens Q9Y259
-
-
2.7.1.32 Mus musculus Q54AG5 subtype alpha
-
2.7.1.32 Mus musculus Q54AG5 subtype beta
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.32 ATP + choline
-
 Mus musculus ADP + O-phosphocholine
-
 ?
2.7.1.32 ATP + choline
-
 Homo sapiens ADP + O-phosphocholine
-
 ?
2.7.1.32 ATP + choline initial step of the Kennedy pathway, that yields phosphatidylcholine as final product, involved in mitogenic signaling transduction Mus musculus ADP + O-phosphocholine
-
 ?
2.7.1.32 ATP + choline initial step of the Kennedy pathway, that yields phosphatidylcholine as final product, involved in mitogenic signaling transduction, the product O-phosphocholine serves as second messenger and is essential for cell growth, enzyme plays a role in tumor generation Homo sapiens ADP + O-phosphocholine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.32 oligomer mainly dimers and tetramers, x * 50000 Homo sapiens
2.7.1.32 oligomer subtype alpha, mainly dimers and tetramers, x * 50000-52000 Mus musculus
2.7.1.32 oligomer subtype beta, mainly dimers and tetramers, x * 42000 Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.7.1.32 More two subtypes identified which are named alpha and beta (ChoKalpha and ChoKbeta), alpha subtype displays two splicing variants names alpha1 and alpha2 Mus musculus