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Literature summary extracted from

  • Verbsky, J.; Lavine, K.; Majerus, P.W.
    Disruption of the mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene, associated lethality, and tissue distribution of 2-kinase expression (2005), Proc. Natl. Acad. Sci. USA, 102, 8448-8453.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.158 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate Mus musculus it is suggested that the enzyme is necessary for yolk sac development or function. Loss of inositol 1,3,4,5,6-pentakisphosphate 2-kinase is lethal ADP + 1D-myo-inositol hexakisphosphate
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?
2.7.1.158 additional information Mus musculus loss of the 2-kinase is lethal ?
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?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.158 Mus musculus
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.158 cardiac myocyte
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Mus musculus
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2.7.1.158 cerebellar cortex
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Mus musculus
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2.7.1.158 cerebellar Purkinje cell
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Mus musculus
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2.7.1.158 cerebellum
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Mus musculus
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2.7.1.158 cerebellum Purkinje layer of the cerebellum Mus musculus
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2.7.1.158 ES cell XA232, with a gene trap construct embedded in the inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene Mus musculus
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2.7.1.158 hippocampus
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Mus musculus
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2.7.1.158 myotome of somites Mus musculus
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2.7.1.158 neural tube ventricular layer of neural tube, expressed at day 9.5 postcoitum Mus musculus
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2.7.1.158 neural tube the ventricular layer of the neural tube, at day 9.5 postcoitum, 2-kinase is expressed in the notochord Mus musculus
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2.7.1.158 notochord expressed at day 9.5 postcoitum Mus musculus
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2.7.1.158 notochord at day 9.5 postcoitum, 2-kinase is expressed in the notochord Mus musculus
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2.7.1.158 somite
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Mus musculus
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2.7.1.158 somite myotome of somites. At day 9.5 postcoitum, 2-kinase is expressed in the notochord Mus musculus
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2.7.1.158 testis
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Mus musculus
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2.7.1.158 yolk sac
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Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.158 ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate it is suggested that the enzyme is necessary for yolk sac development or function. Loss of inositol 1,3,4,5,6-pentakisphosphate 2-kinase is lethal Mus musculus ADP + 1D-myo-inositol hexakisphosphate
-
?
2.7.1.158 additional information loss of the 2-kinase is lethal Mus musculus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.158 inositol 1,3,4,5,6-pentakisphosphate 2-kinase
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Mus musculus