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Literature summary extracted from

  • Tian, L.; Coghill, L.S.; McClafferty, H.; MacDonald, S.H.; Antoni, F.A.; Ruth, P.; Knaus, H.G.; Shipston, M.J.
    Distinct stoichiometry of BKCa channel tetramer phosphorylation specifies channel activation and inhibition by cAMP-dependent protein kinase (2004), Proc. Natl. Acad. Sci. USA, 101, 11897-11902.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 cAMP dependent on Homo sapiens
2.7.11.11 cAMP dependent on Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.11 Mg2+
-
 Homo sapiens
2.7.11.11 Mg2+
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.11 ATP + BKCa channel ZERO Homo sapiens recombinant murine HA-tagged tetrameric protein expressed in HEK-293 cells, activity with wild-type and mutant Y334V channel tetramers, but no activity with S899A mutant, phosphorylation at Ser899 activates the channels, overview ADP + phosphorylated BKCa channel ZERO
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Bos taurus
-
-
-
2.7.11.11 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 commercial preparation purified bovine PKA catalytic subunit C Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + BKCa channel ZERO recombinant murine HA-tagged tetrameric protein expressed in HEK-293 cells, activity with wild-type and mutant Y334V channel tetramers, but no activity with S899A mutant, phosphorylation at Ser899 activates the channels, overview Homo sapiens ADP + phosphorylated BKCa channel ZERO
-
 ?
2.7.11.11 ATP + BKCa channel ZERO recombinant murine HA-tagged tetrameric protein expressed in HEK-293 cells, activity with wild-type and mutant Y334V channel tetramers, but no activity with S899A mutant, phosphorylation at Ser899, overview Homo sapiens ADP + phosphorylated BKCa channel ZERO
-
 ?
2.7.11.11 ATP + BKCa channel ZERO recombinant murine HA-tagged tetrameric protein expressed in HEK-293 cells, phosphorylation at Ser899 activates the channel Bos taurus ADP + phosphorylated BKCa channel ZERO
-
 ?
2.7.11.11 ATP + Kemptide
-
 Bos taurus ADP + Kemptide phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKA
-
 Homo sapiens
2.7.11.11 PKA
-
 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.11 30
-
 assay at Homo sapiens
2.7.11.11 30
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.11 7.4
-
 assay at Homo sapiens
2.7.11.11 7.4
-
 assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Homo sapiens
2.7.11.11 ATP
-
 Bos taurus