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Literature summary extracted from

  • Merciris, P.; Claussen, W.J.; Joiner, C.H.; Giraud, F.
    Regulation of K-Cl cotransport by Syk and Src protein tyrosine kinases in deoxygenated sickle cells (2003), Pflugers Arch., 446, 232-238.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.2 additional information deoxygenation of SS cells increases Syk and Lyn PTK activities, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.2 4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine i.e. pp2, inhibits Src family members like Lyn, no inhibition of Syk Homo sapiens
2.7.10.2 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine i.e. pp1, inhibits Src family members like Lyn, no inhibition of Syk Homo sapiens
2.7.10.2 methyl 2,5-dihydroxycinnamate i.e. DHC, inhibition of Syk and Lyn Homo sapiens
2.7.10.2 additional information effects of inhibitors in vivo in SS cells on K-Cl cotransport, overview Homo sapiens
2.7.10.2 staurosporine i.e. ST, inhibition of Syk and Lyn, IC50 for Syk is 0.008 mM Homo sapiens
2.7.10.2 T47 57% inhibition of Syk at 0.1 mM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.10.2 membrane
-
 Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.10.2 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine Homo sapiens activation of Syk is responsible for K-Cl cotransport in SS cells by relieving Src-mediated inhibition of the transporter ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.2 blood
-
 Homo sapiens
-
2.7.10.2 erythrocyte
-
 Homo sapiens
-
2.7.10.2 sickle cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.2 ATP + a [protein]-L-tyrosine activation of Syk is responsible for K-Cl cotransport in SS cells by relieving Src-mediated inhibition of the transporter Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 Lyn
-
 Homo sapiens
2.7.10.2 More Syk belongs to the Syk family of protein tyrosine kinases, Src and Lyn belong to the Src family of protein tyrosine kinases Homo sapiens
2.7.10.2 non-receptor PTK
-
 Homo sapiens
2.7.10.2 Protein tyrosine kinase
-
 Homo sapiens
2.7.10.2 PTK
-
 Homo sapiens
2.7.10.2 Src
-
 Homo sapiens
2.7.10.2 Syk
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.2 ATP
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.10.2 0.008
-
 i.e. ST, inhibition of Syk and Lyn, IC50 for Syk is 0.008 mM Homo sapiens staurosporine