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Literature summary extracted from

  • Krawiec, K.; Kierdaszuk, B.; Kalinichenko, E.N.; Rubinova, E.B.; Mikhailopulo, I.A.; Eriksson, S.; Munch-Petersen, B.; Shugar, D.
    Ability of adenosine-2'(3')-deoxy-3'(2')-triphosphates and related analogues to replace ATP as phosphate donor for all human and Drosphila melanogaster deoxyribonucleoside kinases (2003), Nucleosides Nucleotides Nucleic Acids, 22, 1525-1529.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.76 Mg2+
-
 Homo sapiens
2.7.1.113 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.76 ATP + 2'-deoxyadenosine Homo sapiens
-
 ADP + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.76 ATP + 2'-deoxycytidine Homo sapiens
-
 ADP + 2'-deoxycytidine 5'-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.76 Homo sapiens
-
-
-
2.7.1.113 Homo sapiens
-
-
-
2.7.1.145 Drosophila melanogaster
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.76 0.027
-
 substrate 2'-deoxycytidine and ATP Homo sapiens
2.7.1.76 0.54
-
 substrate 2'-deoxyadenosine and ATP Homo sapiens
2.7.1.113 0.023
-
 substrate 2'-deoxyguanosine and ATP Homo sapiens
2.7.1.145 2.7
-
 substrates 2'-deoxyadenosine and ATP Drosophila melanogaster
2.7.1.145 3
-
 substrates 2'-deoxycytidine and ATP Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.76 2'-deoxyadenosine-3'-fluoro-3'-triphosphate + 2'-deoxyadenosine
-
 Homo sapiens 2'-deoxyadenosine-3'-fluoro-3'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.76 2'-deoxyadenosine-3'-fluoro-3'-triphosphate + 2'-deoxycytidine
-
 Homo sapiens 2'-deoxyadenosine-3'-fluoro-3'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.76 2'-deoxyadenosine-3'-fluoroara-3'-triphosphate + 2'-deoxyadenosine low activity Homo sapiens 2'-deoxyadenosine-3'-fluoroara-3'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.76 2'-deoxyadenosine-3'-fluoroara-3'-triphosphate + 2'-deoxycytidine low activity Homo sapiens 2'-deoxyadenosine-3'-fluoroara-3'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.76 2'-deoxyadenosine-3'-triphosphate + 2'-deoxyadenosine
-
 Homo sapiens 2'-deoxyadenosine-3'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.76 2'-deoxyadenosine-3'-triphosphate + 2'-deoxycytidine
-
 Homo sapiens 2'-deoxyadenosine-3'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.76 3'-deoxyadenosine 2'-triphosphate + 2'-deoxyadenosine
-
 Homo sapiens 3'-deoxyadenosine-2'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.76 3'-deoxyadenosine 2'-triphosphate + 2'-deoxycytidine
-
 Homo sapiens 3'-deoxyadenosine-2'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.76 3'-deoxyadenosine-3'-fluoro-2'-triphosphate + 2'-deoxyadenosine
-
 Homo sapiens 3'-deoxyadenosine-3'-fluoro-2'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.76 3'-deoxyadenosine-3'-fluoro-2'-triphosphate + 2'-deoxycytidine
-
 Homo sapiens 3'-deoxyadenosine-3'-fluoro-2'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.76 3'-deoxyadenosine-3'-fluoroxylo-2'-triphosphate + 2'-deoxyadenosine
-
 Homo sapiens 3'-deoxyadenosine-3'-fluoroxylo-2'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.76 3'-deoxyadenosine-3'-fluoroxylo-2'-triphosphate + 2'-deoxycytidine
-
 Homo sapiens 3'-deoxyadenosine-3'-fluoroxylo-2'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.76 ATP + 2'-deoxyadenosine
-
 Homo sapiens ADP + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.76 ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.113 2'-deoxyadenosine-3'-fluoro-3'-triphosphate + 2'-deoxyguanosine
-
 Homo sapiens 2'-deoxyadenosine-3'-fluoro-3'-diphosphate + 2'-deoxyguanosine 5'-phosphate
-
 ?
2.7.1.113 2'-deoxyadenosine-3'-fluoroara-3'-triphosphate + 2'-deoxyguanosine low activity Homo sapiens 2'-deoxyadenosine-3'-fluoroara-3'-diphosphate + 2'-deoxyguanosine 5'-phosphate
-
 ?
2.7.1.113 2'-deoxyadenosine-3'-triphosphate + 2'-deoxyguanosine
-
 Homo sapiens 2'-deoxyadenosine-3'-diphosphate + 2'-deoxyguanosine 5'-phosphate
-
 ?
2.7.1.113 3'-deoxyadenosine-2'-triphosphate + 2'-deoxyguanosine
-
 Homo sapiens 3'-deoxyadenosine-2'-diphosphate + 2'-deoxyguanosine 5'-phosphate
-
 ?
2.7.1.113 3'-deoxyadenosine-3'-fluoro-2'-triphosphate + 2'-deoxyguanosine
-
 Homo sapiens 3'-deoxyadenosine-3'-fluoro-2'-diphosphate + 2'-deoxyguanosine 5'-phosphate
-
 ?
2.7.1.113 3'-deoxyadenosine-3'-fluoroxylo-2'-triphosphate + 2'-deoxyguanosine
-
 Homo sapiens 3'-deoxyadenosine-3'-fluoroxylo-2'-diphosphate + 2'-deoxyguanosine 5'-phosphate
-
 ?
2.7.1.113 ATP + 2'-deoxyguanosine
-
 Homo sapiens ADP + 2'-deoxyguanosine 5'-phosphate
-
 ?
2.7.1.145 2'-deoxy-2'-fluoroadenosine 3'-triphosphate + 2'-deoxyadenosine low activity Drosophila melanogaster 2'-deoxy-2'-fluoroadenosine 3'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.145 adenosine-2'-deoxy-2'-fluoro-3'-triphosphate + 2'-deoxycytidine low activity Drosophila melanogaster adenosine-2'-deoxy-2'-fluoro-3'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.145 adenosine-2'-deoxy-3'-triphosphate + 2'-deoxyadenosine low activity Drosophila melanogaster adenosine-2'-deoxy-3'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.145 adenosine-2'-deoxy-3'-triphosphate + 2'-deoxycytidine low activity Drosophila melanogaster adenosine-2'-deoxy-3'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.145 adenosine-3'-deoxy-2'-triphosphate + 2'-deoxyadenosine low activity Drosophila melanogaster adenosine-3'-deoxy-2'-diphosphate + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.145 adenosine-3'-deoxy-2'-triphosphate + 2'-deoxycytidine low activity Drosophila melanogaster adenosine-3'-deoxy-2'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.145 adenosine-3'-deoxy-3'-fluoro-2'-triphosphate + 2'-deoxycytidine low activity Drosophila melanogaster adenosine-3'-deoxy-3'-fluoro-2'-diphosphate + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.145 ATP + 2'-deoxyadenosine
-
 Drosophila melanogaster ADP + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.145 ATP + 2'-deoxycytidine
-
 Drosophila melanogaster ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.145 additional information no activity with adenosine-3'-deoxy-3'-fluoroxylo-2'-triphosphate and adenosine-2'-deoxy-3'-fluoroara-3'-triphosphate as phosphate donors Drosophila melanogaster ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.76 dCK
-
 Homo sapiens
2.7.1.113 DGK
-
 Homo sapiens
2.7.1.145 dNK
-
 Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.76 2'-deoxyadenosine-3'-fluoro-3'-triphosphate 62% of the activity with ATP and deoxycytidine, 1.5% of the activity with ATP and deoxyadenosine Homo sapiens
2.7.1.76 2'-deoxyadenosine-3'-fluoroara-3'-triphosphate 59% of the activity with ATP and deoxycytidine, 1% of the activity with ATP and deoxyadenosine Homo sapiens
2.7.1.76 2'-deoxyadenosine-3'-triphosphate 73% of the activity with ATP and deoxycytidine, 6% of the activity with ATP and deoxyadenosine Homo sapiens
2.7.1.76 3'-deoxyadenosine-2'-triphosphate 97% of the activity with ATP and deoxycytidine, 60% of the activity with ATP and deoxyadenosine Homo sapiens
2.7.1.76 3'-deoxyadenosine-3'-fluoro-2'-triphosphate 66% of the activity with ATP and deoxycytidine, 4% of the activity with ATP and deoxyadenosine Homo sapiens
2.7.1.76 3'-deoxyadenosine-3'-fluoroxylo-2'-triphosphate 62% of the activity with ATP and deoxycytidine, 4% of the activity with ATP and deoxyadenosine Homo sapiens
2.7.1.76 ATP
-
 Homo sapiens
2.7.1.113 2'-deoxyadenosine-3'-fluoro-3'-triphosphate 70% of the activity with ATP Homo sapiens
2.7.1.113 2'-deoxyadenosine-3'-fluoroara-3'-triphosphate 13% of the activity with ATP Homo sapiens
2.7.1.113 2'-deoxyadenosine-3'-triphosphate 53% of the activity with ATP Homo sapiens
2.7.1.113 3'-deoxyadenosine-2'-triphosphate 119% of the activity with ATP Homo sapiens
2.7.1.113 3'-deoxyadenosine-3'-fluoro-2'-triphosphate 25% of the activity with ATP Homo sapiens
2.7.1.113 3'-deoxyadenosine-3'-fluoroxylo-2'-triphosphate 55% of the activity with ATP Homo sapiens
2.7.1.113 ATP
-
 Homo sapiens
2.7.1.145 2'-deoxy-2'-fluoroadenosine 3'-triphosphate 0.2-0.6% of the activity with ATP, dependent on the nucleoside substrate Drosophila melanogaster
2.7.1.145 adenosine-2'-deoxy-3'-triphosphate 0.5-1% of the activity with ATP, dependent on the nucleoside substrate Drosophila melanogaster
2.7.1.145 adenosine-3'-deoxy-2'-triphosphate 6-10% of the activity with ATP, dependent on the nucleoside substrate Drosophila melanogaster
2.7.1.145 adenosine-3'-deoxy-3'-fluoro-2'-triphosphate 0.2% of the activity with ATP and 2'deoxycytidine, no activity with 2'-deoxyadenosine Drosophila melanogaster
2.7.1.145 ATP
-
 Drosophila melanogaster