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Literature summary extracted from
- Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase (2004), Nature, 432, 118-122.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 5.4.99.7 | drug development | the enzyme represents a target for the discovery of novel anticholesteraemic drugs | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.4.99.7 | - |
Homo sapiens |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 5.4.99.7 | - |
Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.4.99.7 | Ro 48-8071 | - |
Homo sapiens |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 5.4.99.7 | membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.4.99.7 | 2,3-oxidosqualene | Homo sapiens | - |
lanosterol | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.4.99.7 | Homo sapiens | P48449 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.4.99.7 | 2,3-oxidosqualene | - |
Homo sapiens | lanosterol | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.4.99.7 | lanosterol synthase | - |
Homo sapiens |
| 5.4.99.7 | OSC | - |
Homo sapiens |
| 5.4.99.7 | Oxidosqualene cyclase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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