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Literature summary extracted from

  • Safrany, S.T.
    Protocols for regulation and study of diphosphoinositol polyphosphates (2004), Mol. Pharmacol., 66, 1585-1591.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.4.24 monoperoxo(picolinato)oxovanadate(V) 15fold activation Mesocricetus auratus
2.7.4.24 sorbitol rapid activation in vivo Mesocricetus auratus
2.7.4.24 sucrose rapid activation in vivo Mesocricetus auratus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.24 chlorpromazine inhibition in vivo Mesocricetus auratus
2.7.4.24 genistein rapid inhibition in vivo Mesocricetus auratus
2.7.4.24 additional information no in vivo inhibition by wortmannin, SB203580, i.e. 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, PD98059, i.e. 2'-amino-3'-methoxyflavone, rapamycin, dephostatin, okadaic acid, herbimycin, K-252a, i.e. methyl-(9S,12R)-epoxy-1H-diinodolo[1,2,3-fg:3',2',1'-kI]pyrrolo[3,4-i][1,6]benzodiazocine-2,3,9,10,11,12-hexahydro-(10R)-hydroxy-9-methyl-1-oxo-10-carboxylate, and KN-93, i.e. 2-[N-(4-chlorocinnamoyl)-N-methylbenzylamine] Mesocricetus auratus
2.7.4.24 N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide i.e. W-7, rapid inhibition in vivo Mesocricetus auratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.24 ATP + 5-diphospho-1D-myo-inositol pentakisphosphate Mesocricetus auratus bis(diphospho)-1D-myo-inositol tetrakisphosphate specifically impedes protein trafficking, no regulation by extracellular signal-regulated kinase or phopholipase D ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.24 Mesocricetus auratus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.4.24 cell culture
-
 Mesocricetus auratus
-
2.7.4.24 DDT1-MF-2 cell smooth muscle cell line Mesocricetus auratus
-
2.7.4.24 smooth muscle
-
 Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.24 ATP + 5-diphospho-1D-myo-inositol pentakisphosphate
-
 Mesocricetus auratus ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate
-
 ?
2.7.4.24 ATP + 5-diphospho-1D-myo-inositol pentakisphosphate bis(diphospho)-1D-myo-inositol tetrakisphosphate specifically impedes protein trafficking, no regulation by extracellular signal-regulated kinase or phopholipase D Mesocricetus auratus ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.4.24 ATP
-
 Mesocricetus auratus