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Literature summary extracted from

  • Chamond, N.; Goytia, M.; Coatnoan, N.; Barale, J.C.; Cosson, A.; Degrave, W.M.; Minoprio, P.
    Trypanosoma cruzi proline racemases are involved in parasite differentiation and infectivity (2005), Mol. Microbiol., 58, 46-60.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.1.1.4 extracellular during infection of its mammalian host, the parasite secretes a proline racemase that contributes to parasite immune evasion by acting as a B-cell mitogen Trypanosoma cruzi
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5.1.1.4 intracellular TcPRACB secretes the intracellular isoform of the enzyme. TcPRACA gene can generate both secreted and intracellular isoforms (by an alternative trans-splicing mechanism) Trypanosoma cruzi 5622
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.1.4 L-Pro Trypanosoma cruzi overexpression of TcPRAC leads to an increase in parasite differentiation into infective forms and its subsequent penetration into host cells. During infection of its mammalian host, the parasite secretes a proline racemase that contributes to parasite immune evasion by acting as a B-cell mitogen D-Pro
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 ?

Organism

EC Number Organism UniProt Comment Textmining
5.1.1.4 Trypanosoma cruzi Q4DA80
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.1.4 L-Pro overexpression of TcPRAC leads to an increase in parasite differentiation into infective forms and its subsequent penetration into host cells. During infection of its mammalian host, the parasite secretes a proline racemase that contributes to parasite immune evasion by acting as a B-cell mitogen Trypanosoma cruzi D-Pro
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 ?

Synonyms

EC Number Synonyms Comment Organism
5.1.1.4 TcPRAC
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 Trypanosoma cruzi
5.1.1.4 TcPRACA
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 Trypanosoma cruzi
5.1.1.4 TcPRACB
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 Trypanosoma cruzi