BRENDA - Enzyme Database show

Non-genomic effects of endocrine disrupters: inhibition of estrogen sulfotransferase by phenols and chlorinated phenols

Harris, R.M.; Kirk, C.J.; Waring, R.H.; Mol. Cell. Endocrinol. 244, 72-74 (2005)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.8.2.15
2,3-dichlorophenol
IC50: 0.0007 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
2,4-Dichlorophenol
IC50: 0.0007 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
2,5-dichlorophenol
IC50: 0.0022 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
2,6-dichlorophenol
IC50: 0.0016 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
2-chlorophenol
IC50: 0.02 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
2-phenylphenol
IC50: 0.0052 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
3,4-dichlorophenol
IC50: 0.013 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
3,5-dichlorophenol
IC50: 0.017 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
3-chlorophenol
IC50: 0.13 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
4-chloro-3-methylphenol
IC50: 0.024 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
4-Chlorophenol
IC50: 0.11 mM, vs. 10 nM estradiol
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.8.2.15
cytosol
-
Homo sapiens
5829
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.8.2.15
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.15
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.15
3'-phosphoadenylylsulfate + estradiol
-
662863
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
2.8.2.15
0.0007
-
IC50: 0.0007 mM, vs. 10 nM estradiol
Homo sapiens
2,3-dichlorophenol
2.8.2.15
0.0007
-
IC50: 0.0007 mM, vs. 10 nM estradiol
Homo sapiens
2,4-Dichlorophenol
2.8.2.15
0.0016
-
IC50: 0.0016 mM, vs. 10 nM estradiol
Homo sapiens
2,6-dichlorophenol
2.8.2.15
0.0022
-
IC50: 0.0022 mM, vs. 10 nM estradiol
Homo sapiens
2,5-dichlorophenol
2.8.2.15
0.0052
-
IC50: 0.0052 mM, vs. 10 nM estradiol
Homo sapiens
2-phenylphenol
2.8.2.15
0.013
-
IC50: 0.013 mM, vs. 10 nM estradiol
Homo sapiens
3,4-dichlorophenol
2.8.2.15
0.017
-
IC50: 0.017 mM, vs. 10 nM estradiol
Homo sapiens
3,5-dichlorophenol
2.8.2.15
0.02
-
IC50: 0.02 mM, vs. 10 nM estradiol
Homo sapiens
2-chlorophenol
2.8.2.15
0.024
-
IC50: 0.024 mM, vs. 10 nM estradiol
Homo sapiens
4-chloro-3-methylphenol
2.8.2.15
0.11
-
IC50: 0.11 mM, vs. 10 nM estradiol
Homo sapiens
4-Chlorophenol
2.8.2.15
0.13
-
IC50: 0.13 mM, vs. 10 nM estradiol
Homo sapiens
3-chlorophenol
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
2.8.2.15
0.0007
-
IC50: 0.0007 mM, vs. 10 nM estradiol
Homo sapiens
2,3-dichlorophenol
2.8.2.15
0.0007
-
IC50: 0.0007 mM, vs. 10 nM estradiol
Homo sapiens
2,4-Dichlorophenol
2.8.2.15
0.0016
-
IC50: 0.0016 mM, vs. 10 nM estradiol
Homo sapiens
2,6-dichlorophenol
2.8.2.15
0.0022
-
IC50: 0.0022 mM, vs. 10 nM estradiol
Homo sapiens
2,5-dichlorophenol
2.8.2.15
0.0052
-
IC50: 0.0052 mM, vs. 10 nM estradiol
Homo sapiens
2-phenylphenol
2.8.2.15
0.013
-
IC50: 0.013 mM, vs. 10 nM estradiol
Homo sapiens
3,4-dichlorophenol
2.8.2.15
0.017
-
IC50: 0.017 mM, vs. 10 nM estradiol
Homo sapiens
3,5-dichlorophenol
2.8.2.15
0.02
-
IC50: 0.02 mM, vs. 10 nM estradiol
Homo sapiens
2-chlorophenol
2.8.2.15
0.024
-
IC50: 0.024 mM, vs. 10 nM estradiol
Homo sapiens
4-chloro-3-methylphenol
2.8.2.15
0.11
-
IC50: 0.11 mM, vs. 10 nM estradiol
Homo sapiens
4-Chlorophenol
2.8.2.15
0.13
-
IC50: 0.13 mM, vs. 10 nM estradiol
Homo sapiens
3-chlorophenol
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.8.2.15
2,3-dichlorophenol
IC50: 0.0007 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
2,4-Dichlorophenol
IC50: 0.0007 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
2,5-dichlorophenol
IC50: 0.0022 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
2,6-dichlorophenol
IC50: 0.0016 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
2-chlorophenol
IC50: 0.02 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
2-phenylphenol
IC50: 0.0052 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
3,4-dichlorophenol
IC50: 0.013 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
3,5-dichlorophenol
IC50: 0.017 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
3-chlorophenol
IC50: 0.13 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
4-chloro-3-methylphenol
IC50: 0.024 mM, vs. 10 nM estradiol
Homo sapiens
2.8.2.15
4-Chlorophenol
IC50: 0.11 mM, vs. 10 nM estradiol
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.8.2.15
cytosol
-
Homo sapiens
5829
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.8.2.15
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.8.2.15
3'-phosphoadenylylsulfate + estradiol
-
662863
Homo sapiens
adenosine 3',5'-bisphosphate + ?
-
-
-
?