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Literature summary extracted from

  • Harris, R.M.; Kirk, C.J.; Waring, R.H.
    Non-genomic effects of endocrine disrupters: inhibition of estrogen sulfotransferase by phenols and chlorinated phenols (2005), Mol. Cell. Endocrinol., 244, 72-74.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.15 2,3-dichlorophenol IC50: 0.0007 mM, vs. 10 nM estradiol Homo sapiens
2.8.2.15 2,4-Dichlorophenol IC50: 0.0007 mM, vs. 10 nM estradiol Homo sapiens
2.8.2.15 2,5-dichlorophenol IC50: 0.0022 mM, vs. 10 nM estradiol Homo sapiens
2.8.2.15 2,6-dichlorophenol IC50: 0.0016 mM, vs. 10 nM estradiol Homo sapiens
2.8.2.15 2-chlorophenol IC50: 0.02 mM, vs. 10 nM estradiol Homo sapiens
2.8.2.15 2-phenylphenol IC50: 0.0052 mM, vs. 10 nM estradiol Homo sapiens
2.8.2.15 3,4-dichlorophenol IC50: 0.013 mM, vs. 10 nM estradiol Homo sapiens
2.8.2.15 3,5-dichlorophenol IC50: 0.017 mM, vs. 10 nM estradiol Homo sapiens
2.8.2.15 3-chlorophenol IC50: 0.13 mM, vs. 10 nM estradiol Homo sapiens
2.8.2.15 4-chloro-3-methylphenol IC50: 0.024 mM, vs. 10 nM estradiol Homo sapiens
2.8.2.15 4-Chlorophenol IC50: 0.11 mM, vs. 10 nM estradiol Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.15 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.15 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.15 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.15 3'-phosphoadenylylsulfate + estradiol
-
 Homo sapiens adenosine 3',5'-bisphosphate + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.15 SULT 1E1
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.8.2.15 0.0007
-
 IC50: 0.0007 mM, vs. 10 nM estradiol Homo sapiens 2,4-Dichlorophenol
2.8.2.15 0.0007
-
 IC50: 0.0007 mM, vs. 10 nM estradiol Homo sapiens 2,3-dichlorophenol
2.8.2.15 0.0016
-
 IC50: 0.0016 mM, vs. 10 nM estradiol Homo sapiens 2,6-dichlorophenol
2.8.2.15 0.0022
-
 IC50: 0.0022 mM, vs. 10 nM estradiol Homo sapiens 2,5-dichlorophenol
2.8.2.15 0.0052
-
 IC50: 0.0052 mM, vs. 10 nM estradiol Homo sapiens 2-phenylphenol
2.8.2.15 0.013
-
 IC50: 0.013 mM, vs. 10 nM estradiol Homo sapiens 3,4-dichlorophenol
2.8.2.15 0.017
-
 IC50: 0.017 mM, vs. 10 nM estradiol Homo sapiens 3,5-dichlorophenol
2.8.2.15 0.02
-
 IC50: 0.02 mM, vs. 10 nM estradiol Homo sapiens 2-chlorophenol
2.8.2.15 0.024
-
 IC50: 0.024 mM, vs. 10 nM estradiol Homo sapiens 4-chloro-3-methylphenol
2.8.2.15 0.11
-
 IC50: 0.11 mM, vs. 10 nM estradiol Homo sapiens 4-Chlorophenol
2.8.2.15 0.13
-
 IC50: 0.13 mM, vs. 10 nM estradiol Homo sapiens 3-chlorophenol