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Literature summary extracted from

  • Lee, H.; Rezai-Zadeh, N.; Seto, E.
    Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A (2004), Mol. Cell. Biol., 24, 765-773.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 cAMP dependent on Homo sapiens
2.7.11.11 additional information forskolin induces PKA activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.11 H-89 strong inhibition Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.11 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.11 ATP + histone deacetylase 8 Homo sapiens FLAG-tagged class 1 histone deacetylase HDAC8 expressed in HeLa cells via adenovirus infection, phosphorylation at Ser39 reduces the enzyme activity of HDAC8, hyperphosphorylation inhibits the enzyme ADP + phosphorylated histone deacetylase 8
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + histone deacetylase 8 FLAG-tagged class 1 histone deacetylase HDAC8 expressed in HeLa cells via adenovirus infection, phosphorylation at Ser39 reduces the enzyme activity of HDAC8, hyperphosphorylation inhibits the enzyme Homo sapiens ADP + phosphorylated histone deacetylase 8
-
 ?
2.7.11.11 ATP + histone deacetylase 8 class 1 histone deacetylase HDAC8, recombinantly expressed FLAG-tagged GST-fusion substrate protein, Ser39 is the major phosphorylation site, low activity with HDAC8 mutant S39A Homo sapiens ADP + phosphorylated histone deacetylase 8
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 cyclic AMP-dependent protein kinase A
-
 Homo sapiens
2.7.11.11 PKA
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.11 30
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Homo sapiens