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Literature summary extracted from

  • Hilder, T.L.; Carlson, G.M.; Haystead, T.A.; Krebs, E.G.; Graves, L.M.
    Caspase-3 dependent cleavage and activation of skeletal muscle phosphorylase b kinase (2005), Mol. Cell. Biochem., 275, 233-242.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.19 caspase-3 selective in vitro cleavage of the regulatory alpha-subunit increasing the enzyme activity 2fold Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.19 additional information after treatment of differentiated C2C12 muscle myoblasts with apoptosis inducers staurosporine, N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine, doxorubicin, or UV radiation the enzyme alpha-subunit disappears Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.19 Ca2+
-
 Oryctolagus cuniculus
2.7.11.19 Mg2+
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.19 ATP + glycogen phosphorylase b Mus musculus key enzyme in conversion of glycogen to glucose in skeletal muscle, regulation of enzyme activity during apoptosis, overview ADP + glycogen phosphorylase a
-
 ?
2.7.11.19 ATP + glycogen phosphorylase b Oryctolagus cuniculus key enzyme in conversion of glycogen to glucose in skeletal muscle, regulation of enzyme activity during apoptosis, overview ADP + glycogen phosphorylase a
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.19 Mus musculus
-
-
-
2.7.11.19 Oryctolagus cuniculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.19 proteolytic modification specific cleavage of caspase-3 at a specific cleavage site within the alpha-subunit at residue 46 in the sequence DWMD*G Oryctolagus cuniculus
2.7.11.19 proteolytic modification specific cleavage of caspase-3 at a specific cleavage site within the alpha-subunit in vivo Mus musculus

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.19
-
 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.19 C2C12 cell differentiated muscle myoblasts Mus musculus
-
2.7.11.19 myoblast muscle cells Mus musculus
-
2.7.11.19 skeletal muscle
-
 Mus musculus
-
2.7.11.19 skeletal muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.19 ATP + glycogen phosphorylase b
-
 Mus musculus ADP + glycogen phosphorylase a
-
 ?
2.7.11.19 ATP + glycogen phosphorylase b
-
 Oryctolagus cuniculus ADP + glycogen phosphorylase a
-
 ?
2.7.11.19 ATP + glycogen phosphorylase b key enzyme in conversion of glycogen to glucose in skeletal muscle, regulation of enzyme activity during apoptosis, overview Mus musculus ADP + glycogen phosphorylase a
-
 ?
2.7.11.19 ATP + glycogen phosphorylase b key enzyme in conversion of glycogen to glucose in skeletal muscle, regulation of enzyme activity during apoptosis, overview Oryctolagus cuniculus ADP + glycogen phosphorylase a
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.19 hexadecamer (alphabetagammadelta)4 Oryctolagus cuniculus
2.7.11.19 More calmodulin is identical with the delta subunit Oryctolagus cuniculus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.19 PhK
-
 Mus musculus
2.7.11.19 PhK
-
 Oryctolagus cuniculus
2.7.11.19 Phosphorylase b kinase
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.19 30
-
 assay at Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.19 6.8
-
 assay at Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.19 ATP
-
 Mus musculus
2.7.11.19 ATP
-
 Oryctolagus cuniculus
2.7.11.19 Calmodulin identical with the delta subunit Mus musculus
2.7.11.19 Calmodulin identical with the delta subunit Oryctolagus cuniculus