EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
6.3.4.4 | D-fructose 1,6-diphosphate | activates | Plasmodium falciparum |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
6.3.4.4 | adenylosuccinate | competitive versus IMP, non-competitive versus GTP and aspartate | Plasmodium falciparum | |
6.3.4.4 | AMP | competitive versus IMP, non-competitive versus GTP and non-competitive versus aspartate | Plasmodium falciparum | |
6.3.4.4 | GDP | uncompetitive versus IMP, competitive versus GTP and non-competitive versus aspartate | Plasmodium falciparum | |
6.3.4.4 | GMP | uncompetitive versus IMP, competitive versus GTP and non-competitive versus aspartate | Plasmodium falciparum | |
6.3.4.4 | Hadacidin | uncompetitive versus IMP and GTP, competitive versus aspartate | Plasmodium falciparum |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
6.3.4.4 | 0.0184 | - |
GTP | pH 7.5 | Plasmodium falciparum | |
6.3.4.4 | 0.023 | - |
IMP | pH 7.5 | Plasmodium falciparum | |
6.3.4.4 | 1.8 | - |
L-aspartate | pH 7.5 | Plasmodium falciparum |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
6.3.4.4 | Mg2+ | dependent on | Plasmodium falciparum |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.3.4.4 | Plasmodium falciparum | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
6.3.4.4 | - |
Plasmodium falciparum |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.3.4.4 | GTP + IMP + L-aspartate | - |
Plasmodium falciparum | GDP + phosphate + adenylosuccinate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
6.3.4.4 | PfAdSS | - |
Plasmodium falciparum |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
6.3.4.4 | 1.1 | - |
GTP | pH 7.5 | Plasmodium falciparum | |
6.3.4.4 | 1.1 | - |
L-aspartate | pH 7.5 | Plasmodium falciparum | |
6.3.4.4 | 1.1 | - |
IMP | pH 7.5 | Plasmodium falciparum |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
6.3.4.4 | 0.0053 | - |
GDP | pH 7.5 | Plasmodium falciparum | |
6.3.4.4 | 0.019 | - |
GMP | pH 7.5 | Plasmodium falciparum | |
6.3.4.4 | 0.029 | - |
adenylosuccinate | pH 7.5 | Plasmodium falciparum | |
6.3.4.4 | 0.066 | - |
AMP | pH 7.5 | Plasmodium falciparum |