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Literature summary extracted from

  • Luu-The, V.; Pelletier, G.; Labrie, F.
    Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase (2005), J. Steroid Biochem. Mol. Biol., 93, 269-276.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.99.5 progesterone + reduced acceptor Mus musculus
-
 5alpha-pregnan-3,20-dione + acceptor
-
 ?
1.3.99.5 testosterone + reduced acceptor Mus musculus
-
 5alpha-dihydrotestosterone + acceptor
-
 ?
2.8.2.4 additional information Mus musculus the role of the enzyme is most probably to protect male tissues against estronic action ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.99.5 Mus musculus
-
-
-
2.8.2.4 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.99.5 adrenal gland abnormally high expression of isoform 2 enzyme in male and female Mus musculus
-
1.3.99.5 prostate gland type 2 5alpha-reductase mRNA is predominantly expressed in the prostate gland Mus musculus
-
1.3.99.5 uterus type 1 5alpha-reductase is predominantly expressed in the uterus Mus musculus
-
2.8.2.4 additional information absent in mammary gland, uterus and overy Mus musculus
-
2.8.2.4 prostate male-specific enzyme Mus musculus
-
2.8.2.4 seminal vesicle male-specific enzyme Mus musculus
-
2.8.2.4 testis male-specific enzyme Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.99.5 progesterone + reduced acceptor
-
 Mus musculus 5alpha-pregnan-3,20-dione + acceptor
-
 ?
1.3.99.5 testosterone + reduced acceptor
-
 Mus musculus 5alpha-dihydrotestosterone + acceptor
-
 ?
2.8.2.4 additional information the role of the enzyme is most probably to protect male tissues against estronic action Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.99.5 type 2 5alpha-reductase
-
 Mus musculus
2.8.2.4 estrogen sulfotransferase
-
 Mus musculus
2.8.2.4 SULT1E1
-
 Mus musculus