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Literature summary extracted from

  • Sedej, S.; Rose, T.; Rupnik, M.
    cAMP increases Ca2+-dependent exocytosis through both PKA and Epac2 in mouse melanotrophs from pituitary tissue slices (2005), J. Physiol., 567, 799-813.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 cAMP dependent on Mus musculus
2.7.11.11 additional information PKA is induced by oestrogen 17beta-oestradiol and forskolin Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.11 cytosol
-
 Mus musculus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.11 Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.11 additional information Mus musculus oestrogen-dependent increase in cAMP increases Ca2+-dependent exocytosis through protein kinase A-dependent pathway and through alternative cAMP-guanine nucleotide exchange factor GEF/Epac-dependent pathway in secretory cells ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Mus musculus
-
 pregnant female and male NMRI mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 melanotroph
-
 Mus musculus
-
2.7.11.11 pituitary gland
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.11 additional information
-
 measurement of cytosolic Ca2+ concentrations Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 additional information oestrogen-dependent increase in cAMP increases Ca2+-dependent exocytosis through protein kinase A-dependent pathway and through alternative cAMP-guanine nucleotide exchange factor GEF/Epac-dependent pathway in secretory cells Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKA
-
 Mus musculus
2.7.11.11 protein kinase A
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Mus musculus