Literature summary extracted from

Jin, Q.; Williams, D.C.; Hezari, M.; Croteau, R.; Coates, R.M.
Stereochemistry of the macrocyclization and elimination steps in taxadiene biosynthesis through deuterium labeling (2005), J. Org. Chem., 70, 4667-4675.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
4.2.3.17	(E,E,E)-geranylgeranyl diphosphate	Taxus brevifolia	first committed step of taxol biosynthesis	taxa-4(5),11(12)-diene + diphosphate	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.2.3.17	Taxus brevifolia	-	recombinant	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.2.3.17	(E,E,E)-geranylgeranyl diphosphate	first committed step of taxol biosynthesis	Taxus brevifolia	taxa-4(5),11(12)-diene + diphosphate	-	?
4.2.3.17	(E,E,E)-geranylgeranyl diphosphate	mechanism of cyclization. Incubation of (R)-[4-2H1]geranylgeranyl diphosphate gives a 10:10:80 mixture of [5beta-2H1]taxa-3(4),11(12)-diens, [5beta-2H1]taxa-4(20),11(12)-diene and unlabeled taxa-4(5),11(12)-diene	Taxus brevifolia	taxa-4,11-diene + diphosphate	-	?

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Release 2023.1 (January 2023)