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Literature summary extracted from

  • Leopoldseder, S.; Claren, J.; Jurgens, C.; Sterner, R.
    Interconverting the catalytic activities of (betaalpha)(8)-barrel enzymes from different metabolic pathways: sequence requirements and molecular analysis (2004), J. Mol. Biol., 337, 871-879.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
5.3.1.16 D127F mutation generates phosphoribosylanthranilate isomerase activity Thermotoga maritima
5.3.1.16 D127G mutation generates phosphoribosylanthranilate isomerase activity Thermotoga maritima
5.3.1.16 D127K mutation generates phosphoribosylanthranilate isomerase activity Thermotoga maritima
5.3.1.16 D127T mutation generates phosphoribosylanthranilate isomerase activity Thermotoga maritima
5.3.1.16 D127V mutation generates phosphoribosylanthranilate isomerase activity Thermotoga maritima
5.3.1.16 D127V/T164H mutation generates phosphoribosylanthranilate isomerase activity Thermotoga maritima

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.3.1.16 additional information
-
additional information Km-values for phosphoribosylanthranilate of mutant enzymes D127V, D127K, D127T, D127G, D127F and D127V/T164H Thermotoga maritima
5.3.1.24 0.026
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D127G, mutant form of EC 5.3.1.6 Thermotoga maritima
5.3.1.24 0.03
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D127K, mutant form of EC 5.3.1.6 Thermotoga maritima
5.3.1.24 0.04
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D130P, mutant form of imidazole glycerol phosphate synthase Thermotoga maritima
5.3.1.24 0.041
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D127F, mutant form of EC 5.3.1.6 Thermotoga maritima
5.3.1.24 0.043
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D127T, mutant form of EC 5.3.1.6 Thermotoga maritima
5.3.1.24 0.045
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D130T, mutant form of imidazole glycerol phosphate synthase Thermotoga maritima
5.3.1.24 0.051
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D127V/T164H, mutant form of EC 5.3.1.6 Thermotoga maritima
5.3.1.24 0.074
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D127V, mutant form of EC 5.3.1.6 Thermotoga maritima
5.3.1.24 0.074
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D130V, mutant form of imidazole glycerol phosphate synthase Thermotoga maritima

Organism

EC Number Organism UniProt Comment Textmining
5.3.1.16 Thermotoga maritima
-
-
-
5.3.1.24 Thermotoga maritima
-
imidazole glycerol phosphate synthase mutant enzyme forms that generate phosphoribosylanthranilate isomerase activity: D130V, D130T, D130P. Mutant form of EC 5.3.1.6 that generate phosphoribosylanthranilate isomerase activity: D127V, D127K, D127T, D127G, D127F, D127V/T164H
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.1.24 N-(5-phospho-beta-D-ribosyl)anthranilate imidazole glycerol phosphate synthase mutant enzyme forms that generate phosphoribosylanthranilate isomerase activity: D130V, D130T, D130P. Mutant form of EC 5.3.1.6 that generate phosphoribosylanthranilate isomerase activity: D127V, D127K, D127T, D127G, D127F, D127V/T164H Thermotoga maritima 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
5.3.1.16 tHisA
-
Thermotoga maritima
5.3.1.24 More imidazole glycerol phosphate synthase mutant enzyme forms that generate phosphoribosylanthranilate isomerase activity: D130V, D130T, D130P. Mutant form of EC 5.3.1.6 that generate phosphoribosylanthranilate isomerase activity: D127V, D127K, D127T, D127G, D127F, D127V/T164H Thermotoga maritima

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.3.1.16 additional information
-
additional information turnover-numbers for phosphoribosylanthranilate of mutant enzymes D127V, D127K, D127T, D127G, D127F and D127V/T164H Thermotoga maritima
5.3.1.24 0.000092
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D130T, mutant form of imidazole glycerol phosphate synthase Thermotoga maritima
5.3.1.24 0.00018
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D130V, mutant form of imidazole glycerol phosphate synthase Thermotoga maritima
5.3.1.24 0.00022
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D130P, mutant form of imidazole glycerol phosphate synthase Thermotoga maritima
5.3.1.24 0.0013
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D127G, mutant form of EC 5.3.1.6 Thermotoga maritima
5.3.1.24 0.0017
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D127K, mutant form of EC 5.3.1.6 Thermotoga maritima
5.3.1.24 0.0023
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D127F, mutant form of EC 5.3.1.6 Thermotoga maritima
5.3.1.24 0.0027
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D127T, mutant form of EC 5.3.1.6 Thermotoga maritima
5.3.1.24 0.0086
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D127V, mutant form of EC 5.3.1.6 Thermotoga maritima
5.3.1.24 0.009
-
N-(5-phospho-beta-D-ribosyl)anthranilate pH 7.5, 25°C, D127V/T164H, mutant form of EC 5.3.1.6 Thermotoga maritima