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Literature summary extracted from

  • Richards, M.R.; Harp, J.D.; Ory, D.S.; Schaffer, J.E.
    Fatty acid transport protein 1 and long chain acyl CoA synthetase 1 interact in adipocytes (2005), J. Lipid Res., 47, 665-672.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.2.1.3 Triacsin C 90% inhibition at 0.02 mM Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.3 additional information Mus musculus inhibition of ACSL1 activity in adipocytes impairs fatty acid uptake, suggesting that esterification is essential for fatty acid transport. A constitutive interaction between the fatty acid transport protein FATP1 and ACSL1 contributes to efficient cellular uptake of long chain fatty acids in adipocytes through vectorial acylation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.3 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.3 3T3-L1 cell
-
 Mus musculus
-
6.2.1.3 adipocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.3 ATP + oleate + CoA
-
 Mus musculus AMP + diphosphate + oleoyl-CoA
-
 ?
6.2.1.3 additional information inhibition of ACSL1 activity in adipocytes impairs fatty acid uptake, suggesting that esterification is essential for fatty acid transport. A constitutive interaction between the fatty acid transport protein FATP1 and ACSL1 contributes to efficient cellular uptake of long chain fatty acids in adipocytes through vectorial acylation Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
6.2.1.3 More fatty acid transport protein FATP1 and ACSL1 participate in an oligomeric complex in 3T3-L1 adipocytes. The interaction between ACSL1 and FATP1 is constitutive Mus musculus

Synonyms

EC Number Synonyms Comment Organism
6.2.1.3 ACSL
-
 Mus musculus
6.2.1.3 ACSL1
-
 Mus musculus
6.2.1.3 long-chain acyl coenzyme A synthetase 1
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.3 ATP
-
 Mus musculus