Literature summary extracted from

Jiang, Y.J.; Lu, B.; Xu, F.Y.; Gartshore, J.; Taylor, W.A.; Halayko, A.J.; Gonzalez, F.J.; Takasaki, J.; Choy, P.C.; Hatch, G.M.
Stimulation of cardiac cardiolipin biosynthesis by PPARalpha activation (2004), J. Lipid Res., 45, 244-252.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.7.7.41	CTP + phosphatidate	Mus musculus	involved in the de novo biosynthesis of cardiolipin	diphosphate + CDP-diacylglycerol	-	?
2.7.7.41	CTP + phosphatidate	Rattus norvegicus	involved in the de novo biosynthesis of cardiolipin	diphosphate + CDP-diacylglycerol	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.7.41	Mus musculus	-	male C57BL/6N x Sv/129 mice and peroxisome proliferator-activated receptor alpha (PPARalpha) null mice, mice fed ethyl-p-chlorophenoxyisobutyrate (clofibrate) for 14 days, activity is increased by 3-fold in normal mice fed clofibrate but not in PPARalpha null mice	-
2.7.7.41	Rattus norvegicus	-	cultured H9c2 cells	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.7.41	H9c2 cell	embryonic heart myoblastic cells, cells grown in cell culture and treated with ethyl-p-chlorophenoxyisobutyrate (clofibrate), no effect of clofibrate on enzyme activity	Rattus norvegicus	-
2.7.7.41	heart	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.7.41	CTP + phosphatidate	-	Mus musculus	diphosphate + CDP-diacylglycerol	-	?
2.7.7.41	CTP + phosphatidate	-	Rattus norvegicus	diphosphate + CDP-diacylglycerol	-	?
2.7.7.41	CTP + phosphatidate	involved in the de novo biosynthesis of cardiolipin	Mus musculus	diphosphate + CDP-diacylglycerol	-	?
2.7.7.41	CTP + phosphatidate	involved in the de novo biosynthesis of cardiolipin	Rattus norvegicus	diphosphate + CDP-diacylglycerol	-	?

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Release 2023.1 (January 2023)