BRENDA - Enzyme Database

Stimulation of cardiac cardiolipin biosynthesis by PPARalpha activation

Jiang, Y.J.; Lu, B.; Xu, F.Y.; Gartshore, J.; Taylor, W.A.; Halayko, A.J.; Gonzalez, F.J.; Takasaki, J.; Choy, P.C.; Hatch, G.M.; J. Lipid Res. 45, 244-252 (2004)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.7.41
CTP + phosphatidate
Mus musculus
involved in the de novo biosynthesis of cardiolipin
diphosphate + CDP-diacylglycerol
-
-
?
2.7.7.41
CTP + phosphatidate
Rattus norvegicus
involved in the de novo biosynthesis of cardiolipin
diphosphate + CDP-diacylglycerol
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.7.41
Mus musculus
-
male C57BL/6N x Sv/129 mice and peroxisome proliferator-activated receptor alpha (PPARalpha) null mice, mice fed ethyl-p-chlorophenoxyisobutyrate (clofibrate) for 14 days, activity is increased by 3-fold in normal mice fed clofibrate but not in PPARalpha null mice
-
2.7.7.41
Rattus norvegicus
-
cultured H9c2 cells
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.7.41
H9c2 cell
embryonic heart myoblastic cells, cells grown in cell culture and treated with ethyl-p-chlorophenoxyisobutyrate (clofibrate), no effect of clofibrate on enzyme activity
Rattus norvegicus
-
2.7.7.41
heart
-
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.7.41
CTP + phosphatidate
-
662589
Mus musculus
diphosphate + CDP-diacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
-
662589
Rattus norvegicus
diphosphate + CDP-diacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
involved in the de novo biosynthesis of cardiolipin
662589
Mus musculus
diphosphate + CDP-diacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
involved in the de novo biosynthesis of cardiolipin
662589
Rattus norvegicus
diphosphate + CDP-diacylglycerol
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.7.41
CTP + phosphatidate
Mus musculus
involved in the de novo biosynthesis of cardiolipin
diphosphate + CDP-diacylglycerol
-
-
?
2.7.7.41
CTP + phosphatidate
Rattus norvegicus
involved in the de novo biosynthesis of cardiolipin
diphosphate + CDP-diacylglycerol
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.7.41
H9c2 cell
embryonic heart myoblastic cells, cells grown in cell culture and treated with ethyl-p-chlorophenoxyisobutyrate (clofibrate), no effect of clofibrate on enzyme activity
Rattus norvegicus
-
2.7.7.41
heart
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.7.41
CTP + phosphatidate
-
662589
Mus musculus
diphosphate + CDP-diacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
-
662589
Rattus norvegicus
diphosphate + CDP-diacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
involved in the de novo biosynthesis of cardiolipin
662589
Mus musculus
diphosphate + CDP-diacylglycerol
-
-
-
?
2.7.7.41
CTP + phosphatidate
involved in the de novo biosynthesis of cardiolipin
662589
Rattus norvegicus
diphosphate + CDP-diacylglycerol
-
-
-
?