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Literature summary extracted from

  • Browe, D.M.; Baumgarten, C.M.
    Stretch of beta 1 integrin activates an outwardly rectifying chloride current via FAK and Src in rabbit ventricular myocytes (2003), J. Gen. Physiol., 122, 689-702.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.2 additional information Src is activated by mechanical stretch of beta1 integrin, cell swelling and integrin clustering Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.2 4-amino-5-(4-chlorophenyl)-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine i.e. PP2, inhibits Src Oryctolagus cuniculus
2.7.10.2 genistein
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 additional information Oryctolagus cuniculus Src activates an outwardly rectifying chloride current in myocytes being involved in osmotic swelling, enzyme inhibition also inhibits stretch-activated Cl- current, mechanism, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Oryctolagus cuniculus
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 New Zealand white rabbits
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.2 myocyte left ventricular Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 additional information Src activates an outwardly rectifying chloride current in myocytes being involved in osmotic swelling, enzyme inhibition also inhibits stretch-activated Cl- current, mechanism, overview Oryctolagus cuniculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 Protein tyrosine kinase
-
 Oryctolagus cuniculus
2.7.10.2 PTK
-
 Oryctolagus cuniculus
2.7.10.2 Src
-
 Oryctolagus cuniculus