BRENDA - Enzyme Database

Screening of substrate analogs as potential enzyme inhibitors for the arginine kinase of Trypanosoma cruzi

Pereira, C.A.; Alonso, G.D.; Ivaldi, S.; Bouvier, L.A.; Torres, H.N.; Flawia, M.M.; J. Eukaryot. Microbiol. 50, 132-134 (2003)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.3.3
agmatine
10 mM, 79.3% inhibition
Trypanosoma cruzi
2.7.3.3
aminoguanidine
10 mM, 2.6% inhibition
Trypanosoma cruzi
2.7.3.3
canavanine
10 mM, 54.6% inhibition
Trypanosoma cruzi
2.7.3.3
Creatine
10 mM, 12.7% inhibition
Trypanosoma cruzi
2.7.3.3
guanidine butyrate
10 mM, 4.3% inhibition
Trypanosoma cruzi
2.7.3.3
homoarginine
10 mM, 38.2% inhibition
Trypanosoma cruzi
2.7.3.3
L-histidine
10 mM, 2.4% inhibition
Trypanosoma cruzi
2.7.3.3
L-nitroarginine
10 mM, 52.6% inhibition
Trypanosoma cruzi
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.3.3
Trypanosoma cruzi
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.3.3
epimastigote
-
Trypanosoma cruzi
-
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.7.3.3
6.02
-
homoarginine
-
Trypanosoma cruzi
2.7.3.3
7.55
-
canavanine
-
Trypanosoma cruzi
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.7.3.3
agmatine
10 mM, 79.3% inhibition
Trypanosoma cruzi
2.7.3.3
aminoguanidine
10 mM, 2.6% inhibition
Trypanosoma cruzi
2.7.3.3
canavanine
10 mM, 54.6% inhibition
Trypanosoma cruzi
2.7.3.3
Creatine
10 mM, 12.7% inhibition
Trypanosoma cruzi
2.7.3.3
guanidine butyrate
10 mM, 4.3% inhibition
Trypanosoma cruzi
2.7.3.3
homoarginine
10 mM, 38.2% inhibition
Trypanosoma cruzi
2.7.3.3
L-histidine
10 mM, 2.4% inhibition
Trypanosoma cruzi
2.7.3.3
L-nitroarginine
10 mM, 52.6% inhibition
Trypanosoma cruzi
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.7.3.3
6.02
-
homoarginine
-
Trypanosoma cruzi
2.7.3.3
7.55
-
canavanine
-
Trypanosoma cruzi
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.3.3
epimastigote
-
Trypanosoma cruzi
-