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Literature summary extracted from

  • Hubeek, I.; Peters, G.J.; Broekhuizen, A.J.F.; Talianidis, I.; Sigmond, J.; Gibson, B.E.S.; Creutzig, U.; Giaccone, G.; Kaspers, G.J.L.
    Immunocytochemical detection of deoxycytidine kinase in haematological malignancies and solid tumours (2005), J. Clin. Pathol., 58, 695-699.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.74 Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.74 ATP + 2'-deoxycytidine Homo sapiens
-
ADP + 2'-deoxycytidine 5'-phosphate
-
?
2.7.1.74 ATP + 2-chlorodeoxyadenosine Homo sapiens i.e. cladribine ADP + 2-chlorodeoxyadenosine 5'-phosphate
-
?
2.7.1.74 additional information Homo sapiens the enzyme is active and important in activation of several clinically important deoxynucleoside analogues used for the treatment of haematological and solid malignancies ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 brain tumor cell paediatric Homo sapiens
-
2.7.1.74 CCRF-CEM cell
-
Homo sapiens
-
2.7.1.74 HL-60 cell
-
Homo sapiens
-
2.7.1.74 lung cancer cell adult non-small cell lung cancer Homo sapiens
-
2.7.1.74 additional information enzyme level in case of acute myeloid leukemia and acute lymphoblastic leukemia in 97 patients, expression levels in different cancer cells, overview Homo sapiens
-
2.7.1.74 retinoblastoma cell
-
Homo sapiens
-
2.7.1.74 U-937 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 ATP + 2'-deoxycytidine
-
Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
?
2.7.1.74 ATP + 2-chlorodeoxyadenosine i.e. cladribine Homo sapiens ADP + 2-chlorodeoxyadenosine 5'-phosphate
-
?
2.7.1.74 additional information the enzyme is active and important in activation of several clinically important deoxynucleoside analogues used for the treatment of haematological and solid malignancies Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.74 ATP
-
Homo sapiens