BRENDA - Enzyme Database show

Immunocytochemical detection of deoxycytidine kinase in haematological malignancies and solid tumours

Hubeek, I.; Peters, G.J.; Broekhuizen, A.J.F.; Talianidis, I.; Sigmond, J.; Gibson, B.E.S.; Creutzig, U.; Giaccone, G.; Kaspers, G.J.L.; J. Clin. Pathol. 58, 695-699 (2005)

Data extracted from this reference:

Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.1.74
Mg2+
-
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
Homo sapiens
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
2.7.1.74
ATP + 2-chlorodeoxyadenosine
Homo sapiens
i.e. cladribine
ADP + 2-chlorodeoxyadenosine 5'-phosphate
-
-
?
2.7.1.74
additional information
Homo sapiens
the enzyme is active and important in activation of several clinically important deoxynucleoside analogues used for the treatment of haematological and solid malignancies
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.74
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
brain tumor cell
paediatric
Homo sapiens
-
2.7.1.74
CCRF-CEM cell
-
Homo sapiens
-
2.7.1.74
HL-60 cell
-
Homo sapiens
-
2.7.1.74
lung cancer cell
adult non-small cell lung cancer
Homo sapiens
-
2.7.1.74
additional information
enzyme level in case of acute myeloid leukemia and acute lymphoblastic leukemia in 97 patients, expression levels in different cancer cells, overview
Homo sapiens
-
2.7.1.74
retinoblastoma cell
-
Homo sapiens
-
2.7.1.74
U-937 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
662521
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + 2-chlorodeoxyadenosine
i.e. cladribine
662521
Homo sapiens
ADP + 2-chlorodeoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.74
additional information
the enzyme is active and important in activation of several clinically important deoxynucleoside analogues used for the treatment of haematological and solid malignancies
662521
Homo sapiens
?
-
-
-
-
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Homo sapiens
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.1.74
Mg2+
-
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
Homo sapiens
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
2.7.1.74
ATP + 2-chlorodeoxyadenosine
Homo sapiens
i.e. cladribine
ADP + 2-chlorodeoxyadenosine 5'-phosphate
-
-
?
2.7.1.74
additional information
Homo sapiens
the enzyme is active and important in activation of several clinically important deoxynucleoside analogues used for the treatment of haematological and solid malignancies
?
-
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
brain tumor cell
paediatric
Homo sapiens
-
2.7.1.74
CCRF-CEM cell
-
Homo sapiens
-
2.7.1.74
HL-60 cell
-
Homo sapiens
-
2.7.1.74
lung cancer cell
adult non-small cell lung cancer
Homo sapiens
-
2.7.1.74
additional information
enzyme level in case of acute myeloid leukemia and acute lymphoblastic leukemia in 97 patients, expression levels in different cancer cells, overview
Homo sapiens
-
2.7.1.74
retinoblastoma cell
-
Homo sapiens
-
2.7.1.74
U-937 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
662521
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + 2-chlorodeoxyadenosine
i.e. cladribine
662521
Homo sapiens
ADP + 2-chlorodeoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.74
additional information
the enzyme is active and important in activation of several clinically important deoxynucleoside analogues used for the treatment of haematological and solid malignancies
662521
Homo sapiens
?
-
-
-
-