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Literature summary extracted from

  • Luo, J.L.; Kamata, H.; Karin, M.
    IKK/NF-kappaB signaling: balancing life and death - a new approach to cancer therapy (2005), J. Clin. Invest., 115, 2625-2632.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.10 TNFalpha and other cytokines, activation of IKK activating NF-kappaB Mus musculus
2.7.11.10 TNFalpha and other cytokines, activation of IKK activating NF-kappaB Homo sapiens

Application

EC Number Application Comment Organism
2.7.11.10 medicine inhibition of IKK-driven NF-kappaB activation offers a strategy for treatment of different malignancies and can convert inflammation-induced tumor growth to inflammation-induced tumor regression Homo sapiens
2.7.11.10 pharmacology IKKbeta/NF-kappaB inhibitors can be useful adjuvants for conventional chemotherapeutic drugs, ionizing radiation, or tumoricidal cytokines, e.g. IFNs or TRAIL Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.10 additional information construction of IKK knockout mice as a model system for drug development Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.10 Acetylsalicylic acid nonspecific for IKK, anti-inflammatory Homo sapiens
2.7.11.10 Acetylsalicylic acid nonspecific for IKK, anti-inflammatory Mus musculus
2.7.11.10 arsenic trioxide nonspecific for IKK, acts on a cystein ersidue in the activation loop Homo sapiens
2.7.11.10 arsenic trioxide nonspecific for IKK, acts on a cystein ersidue in the activation loop Mus musculus
2.7.11.10 AS602868 IKKbeta inhibitor Homo sapiens
2.7.11.10 AS602868 IKKbeta inhibitor Mus musculus
2.7.11.10 cyclopentenone prostaglandins nonspecific for IKK, anti-inflammatory Homo sapiens
2.7.11.10 cyclopentenone prostaglandins nonspecific for IKK, anti-inflammatory Mus musculus
2.7.11.10 sulfasalazine nonspecific for IKK, anti-inflammatory Homo sapiens
2.7.11.10 sulfasalazine nonspecific for IKK, anti-inflammatory Mus musculus
2.7.11.10 sulindac sulfide nonspecific for IKK, anti-inflammatory Homo sapiens
2.7.11.10 sulindac sulfide nonspecific for IKK, anti-inflammatory Mus musculus
2.7.11.10 trans-resveratrol nonspecific for IKK, anti-inflammatory Homo sapiens
2.7.11.10 trans-resveratrol nonspecific for IKK, anti-inflammatory Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.10 cytoplasm
-
 Mus musculus 5737
-
2.7.11.10 cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein] Mus musculus
-
 ADP + [IkappaB phosphoprotein]
-
 ?
2.7.11.10 ATP + [IkappaB protein] Homo sapiens
-
 ADP + [IkappaB phosphoprotein]
-
 ?
2.7.11.10 additional information Mus musculus IKK activates NF-kappaB which initiates signaling pathways that play critical roles in a variety of physiological and pathological processes, e.g. promotion of cell survival inducing production of apoptosis inhibitors in normal and cancer cells, pathways overview, IKK/NF-kappaB links inflammation to cancer, regulation of IKK, overview ?
-
 ?
2.7.11.10 additional information Homo sapiens IKK activates NF-kappaB which initiates signaling pathways that play critical roles in a variety of physiological and pathological processes, e.g. promotion of cell survival inducing production of apoptosis inhibitors in normal and cancer cells, pathways overview, IKK/NF-kappaB links inflammation to cancer, regulation of IKK, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.10 Homo sapiens
-
-
-
2.7.11.10 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.10 epidermis
-
 Homo sapiens
-
2.7.11.10 hepatocyte
-
 Mus musculus
-
2.7.11.10 hepatoma cell
-
 Mus musculus
-
2.7.11.10 JURKAT cell
-
 Homo sapiens
-
2.7.11.10 keratinocyte epidermal Homo sapiens
-
2.7.11.10 squamous cell carcinoma cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein]
-
 Mus musculus ADP + [IkappaB phosphoprotein]
-
 ?
2.7.11.10 ATP + [IkappaB protein]
-
 Homo sapiens ADP + [IkappaB phosphoprotein]
-
 ?
2.7.11.10 additional information IKK activates NF-kappaB which initiates signaling pathways that play critical roles in a variety of physiological and pathological processes, e.g. promotion of cell survival inducing production of apoptosis inhibitors in normal and cancer cells, pathways overview, IKK/NF-kappaB links inflammation to cancer, regulation of IKK, overview Mus musculus ?
-
 ?
2.7.11.10 additional information IKK activates NF-kappaB which initiates signaling pathways that play critical roles in a variety of physiological and pathological processes, e.g. promotion of cell survival inducing production of apoptosis inhibitors in normal and cancer cells, pathways overview, IKK/NF-kappaB links inflammation to cancer, regulation of IKK, overview Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.10 More the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and noncatalytic, regulatory NEMO/IKKgamma Mus musculus
2.7.11.10 More the IKK complex consists of 3 subunits: catalytic IKKalpha and IKKbeta, and noncatalytic, regulatory NEMO/IKKgamma Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.11.10 IKK
-
 Mus musculus
2.7.11.10 IKK
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.10 ATP
-
 Mus musculus
2.7.11.10 ATP
-
 Homo sapiens