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Literature summary extracted from

  • Molestina, R.E.; Sinai, A.P.
    Host and parasite-derived IKK activities direct distinct temporal phases of NF-kappaB activation and target gene expression following Toxoplasma gondii infection (2005), J. Cell Sci., 118, 5785-5796.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.11.10 additional information
-
 additional information kinetics of IkappaB phosphorylation by parasite IKK, host NF-kappaB activation reveals a biphasic, hierarchical, and temporally regulated response Toxoplasma gondii

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.10 cytoplasm
-
 Mus musculus 5737
-
2.7.11.10 vacuolar membrane parasitophorous, PVM Toxoplasma gondii 5774
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein] Toxoplasma gondii parasite IKKalpha, localized in parasitophorous vacuole membrane, activates mouse' intracellular NF-kappaB in early infection stage resulting in NF-kappaB nuclear translocation and subsequent gene expression independently from the host IKK complex ADP + [IkappaB phosphoprotein]
-
 ?
2.7.11.10 ATP + [IkappaB protein] Mus musculus required for activation of NF-kappaB resulting in activation of signalling pathways ADP + [IkappaB phosphoprotein]
-
 ?
2.7.11.10 additional information Mus musculus parasite Toxoplasma gondii IKKalpha, localized in parasitophorous vacuole membrane, activates the host intracellular NF-kappaB in early infection stage resulting in NF-kappaB nuclear translocation and subsequent gene expression independently from the host IKK complex ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.10 Mus musculus
-
-
-
2.7.11.10 Toxoplasma gondii
-
 RH strain in mouse embryonic fibroblast host MEF cells, wild-type and IKKalpha- or IKKbeta-deficient host cells
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.10 MEF cell wild-type and IKKalpha- or IKKbeta-deficient embryonic fibroblast cell line infected with parasite Toxoplasma gondii, RH strain Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein]
-
 Mus musculus ADP + [IkappaB phosphoprotein]
-
 ?
2.7.11.10 ATP + [IkappaB protein]
-
 Toxoplasma gondii ADP + [IkappaB phosphoprotein]
-
 ?
2.7.11.10 ATP + [IkappaB protein] parasite IKKalpha, localized in parasitophorous vacuole membrane, activates mouse' intracellular NF-kappaB in early infection stage resulting in NF-kappaB nuclear translocation and subsequent gene expression independently from the host IKK complex Toxoplasma gondii ADP + [IkappaB phosphoprotein]
-
 ?
2.7.11.10 ATP + [IkappaB protein] required for activation of NF-kappaB resulting in activation of signalling pathways Mus musculus ADP + [IkappaB phosphoprotein]
-
 ?
2.7.11.10 additional information parasite Toxoplasma gondii IKKalpha, localized in parasitophorous vacuole membrane, activates the host intracellular NF-kappaB in early infection stage resulting in NF-kappaB nuclear translocation and subsequent gene expression independently from the host IKK complex Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.10 IKK
-
 Mus musculus
2.7.11.10 IKK
-
 Toxoplasma gondii
2.7.11.10 IKK complex
-
 Toxoplasma gondii

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.10 ATP
-
 Mus musculus
2.7.11.10 ATP
-
 Toxoplasma gondii